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Gonadotrophic Hormones

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Gonadotrophic Hormones 

(gonadotrophins), hormones formed by the anterior lobe of the pituitary that regulate the endocrine function of the gonads.

The gonadotrophic hormones include follicle-stimulating hormone (prolan A), luteinizing hormone (prolan B, interstial-cell-stimulating hormone, metakentrin), and luteo-tropic hormone (prolactin, mammotropin, mammogen). In females the gonadotrophic hormones stimulate maturation of the egg cells, ovulation, formation of the corpus luteum (in mammals), and the secretion of estrogens; in males they promote spermatogenesis, the growth of interstitial cells, and the secretion of testosterone. Chorionic gonadotrophin (containing predominantly luteinizing hormone), which is obtained from the urine of pregnant women, and a gonadotrophin from the blood serum of pregnant mares (containing predominantly follicle-stimulating hormone) are used for therapeutic purposes (for example, in disturbances of the menstrual cycle, infertility, hypogenitalism, and obesity).



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Its main products are steroids, synthetic peptides, carbohydrates, gonadotrophic hormones, insulins and heparin.
Transdermal testosterone use has been associated with suppression of pituitary gonadotrophic hormones, luteinizing hormone (LH) and follicle stimulating hormone (FSH), both necessary for stimulating testosterone production and spermatogenesis in the testes.
The improvement in total testosterone in the Androxal arms was the result of normalization of the pituitary gonadotrophic hormones LH (luteinizing hormone) and FSH (follicle stimulating hormone).
 
 
 
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