growth factor

(redirected from Growth factors)
Also found in: Dictionary, Thesaurus, Medical.
Related to Growth factors: Cytokines

Growth factor

Any of a group of biologically active poly-peptides which function as hormonelike regulatory signals, controlling the growth and differentiation of responsive cells. Indeed, the distinction between growth factors and hormones is frequently arbitrary and stems more from the manner of their discovery than from a clear difference in function. See Cell differentiation, Hormone

The sequence of amino acids has been determined for several growth-factor polypeptides. This information permits a number of growth factors to be placed into families, members of which have related amino acid sequences, suggesting that they evolved from a single ancestral protein. The insulin family comprises somatemedins A and C, insulin, insulinlike growth factor (IGF), and multiplication-stimulating factor (MSF). A second family consists of sarcoma growth factor (SGF), transforming growth factors (TGFs), and epidermal growth factor (EGF). In addition, there are growth factors, such as nerve growth factor (NGF), fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF), for which structural homologs have not been identified. See Insulin, Protein

The stimulation of cell proliferation by several growth factors is similar in some ways to the rapid cell proliferation characteristic of tumor cells. Furthermore, the growth factor receptors are similar to the tumor-causing proteins produced by several RNA tumor viruses. It has been demonstrated that platelet-derived growth factor is virtually identical to the tumor-causing protein of the RNA tumor virus, simian sarcoma virus. Some forms of cancer involve improper function of growth factors.

growth factor

[′grōth ‚fak·tər]
(aerospace engineering)
The additional weight of fuel and structural material required by the addition of 1 pound (0.45 kilogram) of payload to the original payload.
(physiology)
Any factor, genetic or extrinsic, which affects growth.
References in periodicals archive ?
In this article, you'll learn about how replenishing four growth factors that decline with aging can boost natural repair mechanisms, in turn reducing wrinkles, improving elasticity, and restoring moisture to rejuvenate aging skin.
The company's STAR (Serial Tethered ARray) growth factor technology works by tethering multiple growth factors to a liquid phase, flexible backbone to form a cluster array, like beads on a string.
Tuominen and colleagues have identified a growth factor that can be used to halt the progress of damage brought on by a nerve poison, and possibly restore the function of damaged cells.
There are also cosmeceuticals that contain different types of growth factors of both plant and animal origin.
Effects ofhematopoietic growth factors on the survival of primitive stem cells in liquid suspension culture.
One tactic encloses growth factors in degradable microspheres and places them in different locations of the polymer material.
Mulder: I'm not at all impressed with the results of past growth factor trials.
Focuses on the interrelationships and convergence of growth factors and their receptors in development and pathogenesis and encourages greater cooperation and integration in the areas of developmental, cancer and cancer therapeutic research
Vascular endothelial growth factor (VEGF) is originally recognized as a vascular permeability factor.
6) In rabbits, Hashimoto et al showed that steroids suppress the formation of granulation tissue (1) by reducing vascular permeability, (2) by decreasing extravasation and the migration of inflammatory cells to the site of infection, (3) by inhibiting the production of a variety of chemotactic factors (especially complement factors and lymphocyte-derived factors), and (4) by acting on growth factors such as vascular endothelial growth factor and transforming growth factor beta.
Under the agreement, BST-GEL(TM), a family of in situ-gelling polymer solutions developed by BIOSYNTECH, will be studied as a carrier for growth factor and gene delivery to accelerate fresh fracture repair of bones.
Previously, researchers were concerned that adding growth factors in high amounts could lead to excessive scarring or possibly cancerous transformations.