growth factor

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Related to Growth factors: Cytokines

Growth factor

Any of a group of biologically active poly-peptides which function as hormonelike regulatory signals, controlling the growth and differentiation of responsive cells. Indeed, the distinction between growth factors and hormones is frequently arbitrary and stems more from the manner of their discovery than from a clear difference in function. See Cell differentiation, Hormone

The sequence of amino acids has been determined for several growth-factor polypeptides. This information permits a number of growth factors to be placed into families, members of which have related amino acid sequences, suggesting that they evolved from a single ancestral protein. The insulin family comprises somatemedins A and C, insulin, insulinlike growth factor (IGF), and multiplication-stimulating factor (MSF). A second family consists of sarcoma growth factor (SGF), transforming growth factors (TGFs), and epidermal growth factor (EGF). In addition, there are growth factors, such as nerve growth factor (NGF), fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF), for which structural homologs have not been identified. See Insulin, Protein

The stimulation of cell proliferation by several growth factors is similar in some ways to the rapid cell proliferation characteristic of tumor cells. Furthermore, the growth factor receptors are similar to the tumor-causing proteins produced by several RNA tumor viruses. It has been demonstrated that platelet-derived growth factor is virtually identical to the tumor-causing protein of the RNA tumor virus, simian sarcoma virus. Some forms of cancer involve improper function of growth factors.

growth factor

[′grōth ‚fak·tər]
(aerospace engineering)
The additional weight of fuel and structural material required by the addition of 1 pound (0.45 kilogram) of payload to the original payload.
Any factor, genetic or extrinsic, which affects growth.
References in periodicals archive ?
I'm thrilled with the recent studies published by the Journal on Growth Factors, as it is an important component for treating multiple skin disorders in our field," says Dr.
Most growth factors applied in stem cell research today are made in E.
TNS Recovery Complex, manufactured by Skin Medica, contains growth factors produced by fibroblast cells, which also make collagen and hyaluronic acid.
Sometimes androgen receptors are bypassed completely, and cell growth is activated by other naturally occurring compounds including insulin-like growth factor-1, epidermal growth factor, and others.
Following the formation of these bodies, the cell population was enriched with specific growth factors to form progenitor cells that expressed genes indicative of the developing inner ear.
Tissue engineers can selectively place different growth factors in different parts of a polymer scaffold, for example, to push a population of stem cells to form multiple layers of different tissue types.
Gastrin also stimulates the secretion and expression of other important growth factors and receptors within and on the surfaces of the cancer cells involved in tumor growth.
We conducted a leg ulcer study with fibroblast growth factors last year, applying them directly into the ulcers.
Provides a fundamental understanding of the basic functions of growth factors and their receptors, describing how they are linked in biological processes
Growth factor therapies have historically been hindered by short half-lives and off-target effects.
Table 9: World 11-Year Perspective for Growth Factors (Blood