Guanidine


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Related to Guanidine: guanidinium

guanidine

[′gwän·ə‚dēn]
(biochemistry)
CH5N2 Aminomethanamidine, a product of protein metabolism found in urine.

Guanidine

 

(also carbamidine). (H2N)2C=NH, colorless hygroscopic crystals; melting point, approximately 50° C. Guanidine absorbs C02 and moisture from the air and forms salts with acids. On hydrolysis it gives urea and ammonia.

Guanidine (or its salts) is obtained by reacting cyanamide with ammonia (or with ammonium salts).

H2N—C≡N + NH3→(H2N)2C═NH

H2N —C≡N +NH4Cl→(H2N)2C═NH.HCI

Guanidine is used to obtain medicinal and explosive substances and ion-exchange resins. A guanidine fragment enters into the composition of guanine (a component of nucleic acids), creatine, and arginine, the antibiotic streptomycin, and tetrodotoxin, a poison of animal origin.

References in periodicals archive ?
In particular, diphenyl guanidine (DPG) is largely used at the industrial scale.
The report includes guanidine hydrochloride description, covers its application areas and related patterns.
We added 200 [micro]L of 5 mol/L guanidine hydrochloride to the spiked CSF (180 [micro]L CSF with 20 [micro]L IS) and vortex-mixed the resulting mixtures at 1000 rpm for 20 min before adding 200 [micro]L of 4% aqueous phosphoric acid (total volume 600 [micro]L).
The Pterogyne nitens (Fabaceae), a tree native to South America, has been found to produce flavonols and guanidine alkaloids (Aller et al.
They differ in the orientation of their fluorine substituent at C3 and whether they contain an amine or a guanidine functional group at C4.
Both urea and guanidine hydrochloride have been shown to improve the wet bond strength of soy protein isolate wood bonds (Huang and Sun 2000a).
If an aqueous sample containing nucleic acids is mixed with suspended silica surfaces, and the solvation properties of the aqueous environment are disrupted (either by addition of alcohols, such as above, or by addition of chaotropic agents such as guanidine.
A combination of carbodihydrazide and organic acid dihydrazide compound such as dihydrazide adipate or dihydrazide succinate with a guanidine salt is especially effective.
2] [35]), hydrogen peroxide (36), mineral acids and carboxylic acids (37), potassium permanganate (38-40), dibutyltin dimethoxide (41), hydrazine hydrate (42), and aqueous guanidine carbonate (43) treatments are reported to increase the stabilization rate considerably while lowering the activation energy of the stabilization reaction.
Although largely resistant, disulphide bonds are broken in alkaline environments (pH 10-14); this explains why afro-textured hair is 'relaxed' permanently using sodium hydroxide or guanidine hydroxide (so-called lye and no-lye relaxers respectively).
DNA extraction and quantitative competitive PCR: Total genomic DNA was isolated from pure culture using Guanidine Thiocyanate-Silica Gel method (Boom et al.

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