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Guanidine
(redirected from Guanidino)

   Also found in: Dictionary/thesaurus, Medical, Wikipedia 0.01 sec.
guanidine [′gwän·ə‚dēn]
(biochemistry)
CH5N2Aminomethanamidine, a product of protein metabolism found in urine.

Guanidine 

(also carbamidine). (H2N)2C=NH, colorless hygroscopic crystals; melting point, approximately 50° C. Guanidine absorbs C02 and moisture from the air and forms salts with acids. On hydrolysis it gives urea and ammonia.

Guanidine (or its salts) is obtained by reacting cyanamide with ammonia (or with ammonium salts).

H2N—C≡N + NH3→(H2N)2C═NH

H2N —C≡N +NH4Cl→(H2N)2C═NH.HCI

Guanidine is used to obtain medicinal and explosive substances and ion-exchange resins. A guanidine fragment enters into the composition of guanine (a component of nucleic acids), creatine, and arginine, the antibiotic streptomycin, and tetrodotoxin, a poison of animal origin.



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CONCLUSIONS: Pharmacologically blocking protein ascorbylation with absorbable guanidino compounds is feasible and may represent a new strategy for the delay of age-related nuclear sclerosis of the lens.
Glycine and arginine combine to release ornithine as a by-product, and form guanidino acetate.
There is significant evidence suggesting that oxygen free radicals play roles in renal ischemia, accumulation of uremic toxins such as urea nitrogen and guanidino compounds, and depletion of SOD, catalase, GSH-Px, and GSH, which are considered to be natural free radical scavengers (De Vecchi et al.
 
 
 
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