Guanidine

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Related to Guanidino: guanidinium

guanidine

[′gwän·ə‚dēn]
(biochemistry)
CH5N2 Aminomethanamidine, a product of protein metabolism found in urine.

Guanidine

 

(also carbamidine). (H2N)2C=NH, colorless hygroscopic crystals; melting point, approximately 50° C. Guanidine absorbs C02 and moisture from the air and forms salts with acids. On hydrolysis it gives urea and ammonia.

Guanidine (or its salts) is obtained by reacting cyanamide with ammonia (or with ammonium salts).

H2N—C≡N + NH3→(H2N)2C═NH

H2N —C≡N +NH4Cl→(H2N)2C═NH.HCI

Guanidine is used to obtain medicinal and explosive substances and ion-exchange resins. A guanidine fragment enters into the composition of guanine (a component of nucleic acids), creatine, and arginine, the antibiotic streptomycin, and tetrodotoxin, a poison of animal origin.

References in periodicals archive ?
Keywords : MEKC, Pyridoin, Guanidino compounds , Uremic patients , Human s erum, Photodiode array detection.
Nitric oxide (NO) is a highly reactive molecule produced from a guanidino nitrogen of arginine by NO synthase (NOS) (7).
Nitric oxide, known as an endothelium-derived relaxing factor, is formed from the terminal guanidino nitrogen atom of L-arginine by NO synthase [10].
La molecula endogena es lipofilica, se forma a partir del grupo guanidino del aminoacido semi esencial L-arginina en su conversion a L-citrulina gracias a la accion de la enzima Oxido Nitrico Sintetasa (ONS) (3, 4, 5, 6, 7, 8); para su sintesis se requiere la presencia de cofactores como: flavin mononucleotido (FMN), flavin adenina dinucleotido (FAD), tetrahidrobiopterina (H4B) y NADPH (9, 10).
Fluorometric determination of monosubstituted guanidino compounds with benzoin-dimethylformamide reagent.
2] and the reduced form of nicotinamide adenine dinucleotide (NADPH), cleaves the terminal guanidino nitrogen from the amino acid L-arginine yielding NO, NADP, and L-citrulline (Moncada et al.
Apos ter origem pelos tres aminoacidos e enzimas, a Cr (acido [alpha]-metil guanidino acetico) e produzida no figado, pancreas e rins (Gama, 2011).
NOS enzymes produce NO by catalyzing a five-electron oxidation of the guanidino nitrogen of L-arginine.
Diurnal changes of free amino acids, amides, and guanidino compounds in roots, buds, and leaves during the onset of dormancy of white spruce saplings.
Re-evaluation of the structure and physiological function of guanidino kinases in the fruit fly (Drosophila), sea urchin (Psammechinus miliaris) and man.
A creatina e uma amina (acido a-metil guanidino acetico) sintetizada no figado, pancreas e rins a partir dos aminoacidos glicina, arginina e metionina.