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CH5N2 Aminomethanamidine, a product of protein metabolism found in urine.



(also carbamidine). (H2N)2C=NH, colorless hygroscopic crystals; melting point, approximately 50° C. Guanidine absorbs C02 and moisture from the air and forms salts with acids. On hydrolysis it gives urea and ammonia.

Guanidine (or its salts) is obtained by reacting cyanamide with ammonia (or with ammonium salts).

H2N—C≡N + NH3→(H2N)2C═NH

H2N —C≡N +NH4Cl→(H2N)2C═NH.HCI

Guanidine is used to obtain medicinal and explosive substances and ion-exchange resins. A guanidine fragment enters into the composition of guanine (a component of nucleic acids), creatine, and arginine, the antibiotic streptomycin, and tetrodotoxin, a poison of animal origin.

References in periodicals archive ?
NOS enzymes produce NO by catalyzing a five-electron oxidation of the guanidino nitrogen of L-arginine.
There is significant evidence suggesting that oxygen free radicals play roles in renal ischemia, accumulation of uremic toxins such as urea nitrogen and guanidino compounds, and depletion of SOD, catalase, GSH-Px, and GSH, which are considered to be natural free radical scavengers (De Vecchi et al.
Guanidino compounds in guanidinoacetate methyltransferase deficiency, a new inborn error of creatine synthesis.
Serum creatine, creatinine, and other guanidino compounds in patients with thyroid dysfunction.
Guanidino compounds in guanidinoacetate methyltransferase defciency, a new inborn error of Creatine synthesis.
Effect of endotoxemia on plasma and tissue levels of nitric oxide metabolites and guanidino compounds.
Aptamers have been shown to discriminate closely related molecules from their targets on the basis of small structural changes, such as a methyl group (25, 26), a hydroxyl group (27, 28), and a urea vs a guanidino group (64).
This heme-containing oxygenase catalyzes a five-electron oxidation from one of the basic guanidino nitrogen atoms of L-arginine in the presence of multiple cofactors and oxygen.