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Nonhuman primate models of HIV-1 infection with either SIV or genetically manipulated pathogenic viruses containing HIV-1 genes recapitulate many of the end-organ pathologies and immune deficiencies seen in humans (20). HGTV 43 contains 3 Enzo-developed antisense genes designed to interfere with the functioning of 2 HIV-1 genes essential for virus growth in human cells. The delivery of the HIV-1 gene into the cells stimulates the body to generate a potent |
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