hapten

(redirected from Haptens)
Also found in: Dictionary, Medical.
Related to Haptens: Epitopes

hapten

(immunology)
An incomplete antigen that cannot induce antibody formation by itself but can do so by coupling with a larger carrier molecule.
References in periodicals archive ?
In vitro and in vivo targeting of radiolabeled monovalent and divalent haptens with dual specificity monoclonal antibody conjugates: Enhanced divalent hapten affinity for cell-bound antibody conjugate.
CHS is a T cell-mediated immune response in the epidermis to a reactive hapten covalently coupled to cell surface proteins (Rowden et al.
We found that six haptens of differing flexibility, in the form of three pairs of enantiomers, failed to induce any catalytic activity in rabbit polyclonal antibodies.
In antibody-hapten binding, the hapten buries itself deep in a cleft-like pocket of the antibody, making contact with relatively few of the antibody's amino acids.
This distance is shorter than the previously observed 5 carbon atoms, or 5A, as the shortest linker between 2 small haptens (histamine and homovanillic acid) that allowed a true sandwich formation for the linear synthetic molecule (16).
Diagram 1: How Food Sensitivities Cause Inflammation Mechanisms * TLR's * Food antigens * Food chemicals * Haptens * Amines * Pharmacologic * Immune Complexes * IgG * IgM * Lectins Cellular Activation * Lymphocytes * Sensitized T-cells * T-Cells * NK Cells * K Cells * Eosinophils * Basophils * Monocytes * Neutrophils Mediator Release * Cytokines * Interleukins * Chemokines * TNFs * Interferons * Leukotrienes * Histamine * ECP.
Reactive drug metabolites can act as haptens through a covalent link with proteins and form an immune-complex protein-drug which, after being processed by antigen-presenting cells, stimulates both cyto-toxic T cells and antibody responses.
Elucidating the various mechanisms of drug injuries is beyond the scope of this article; however, several putative mechanisms exist, with drugs or their metabolites behaving as haptens initiating an idiosyncratic immunological response.
PCR artifacts that contain both haptens will react similarly to the specific products and thus generate a false signal at the target-capture line.
As with most other nonproteinaceous immunogenic substances, sulfonamides act as haptens, becoming covalently linked to a carrier molecule.
Abscripts(R) can be tagged with reporters, affinity tags, or haptens during the Abscription process by incorporating Ribomed's proprietary tagged Ribonucleotide analogs (RiboLogs(R)).
Haptens are nonproteinaceous substances that act as an antigen by combining with particular bonding sites on an antibody.