It has been suggested that the lack of introns in inducible HSP70 genes could help to circumvent blocks in RNA splicing and enable preferential expression of heat shock proteins
during periods of stress (Huang et al.
Exercise Training-Induced Changes in Inflammatory Mediators and Heat Shock Proteins
in Young Tennis Players.
Among the many genes found in the transcriptome, the researchers identified 42 that they think may be responsible for synthesizing heat shock proteins
Given that Fast Track designation is not typically discussed until Phase 2 data is produced, we view the FDA's position as very encouraging for our technology and strategy of targeting heat shock protein
induction as a potential treatment for ALS.
Heat shock proteins
(Hsp) are a common focus in assays used to establish conditions of physiological and environmental stress (Downs et al.
However, because of their occasional unsatisfactory performance, researchers used heat shock protein
60 (Hsp60) as a receptor for Listeria adhesion protein LAP.
These heat shock proteins
are really important in a lot of stress responses.
The new biosensor uses heat shock proteins
instead of the antibodies used in other tests, and tests indicate that the sensor is faster and more sensitive at detecting the bacterium than antibody-based tests, with a microbe capture rate up to 83% greater than possible with the antibody-based tests.
These two peptides, whose discovery was previously disclosed by Compugen, include: a peptide derived from gp96, a member of the HSP90 family, which was shown to possess anti-inflammatory activities in various animal models; and a peptide derived from clusterin, a versatile chaperone molecule which contains characteristics of small Heat Shock Proteins
, which demonstrated positive effects in an animal cancer model.
Heat shock proteins
(HSPs) perform essential biological functions under both physiological and stressful conditions (13-19).
It was therefore proposed that, heat shock proteins
produced by bacteria affecting fish hosts maybe virulence determinants, since without the ability to produce this unique class of protein, bacteria would be incapable of producing disease (Love and hirsh, 1994).
Seventy international academics and researchers contribute 25 chapters on new research in the field of heat shock proteins
(HSP), groups of proteins whose expression is increased when the cells of living organisms are exposed to elevated temperatures or other stress.