heat shock protein

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heat shock protein

[¦hēt ‚shäk ′prō‚tēn]
(cell and molecular biology)
Any of a group of proteins that are synthesized in the cytoplasm of cells as part of the heat shock response and act to protect the chromosomes from damage.
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Heat-shock protein GroE of Escherichia coli: key protective roles against thermal stress.
Scientists had previously observed that tumor cells often have abnormally high quantities of heat-shock proteins.
Heat-shock protein 90 is down-regulated during pupal diapause in the flesh fly, Sarcophaga crassipalpis, but remains responsive to thermal stress.
Heat-shock protein 104 expression is sufficient for thermotolerance in yeast.
Mycobacterial heat-shock proteins generate Th1-type responses, airway inflammation, and hyperresponsiveness (32).
The 90 kDa heat-shock protein (hsp90) modulates the binding of the oestrogen receptor to its cognate DNA.
She found that the immune system in one strain of diabetic mice produced antibodies to their own heat-shock protein 60.
Several research groups have reported TLR reactions to products of mammalian cells: molecules called heat-shock proteins and specific fragments of the blood-clotting protein fibronectin.
When a virus infects a cell, the cell often turns on genes for molecules known as heat-shock proteins.
Microbial cells in which heat-shock proteins are synthesized acquire enhanced thermal tolerance to a second heat challenge that would normally be lethal to them.
In general, heat-shock proteins "prevent unwanted interactions between other proteins," such as clumping or deformation that could alter function, explains Peter Candido of the University of British Columbia in Vancouver.