helicase


Also found in: Dictionary, Medical, Wikipedia.

helicase

[′hel·ə‚kās]
(biochemistry)
An enzyme that is capable of unwinding the deoxyribonucleic acid double helix at a replication fork.
References in periodicals archive ?
A previous study showed that the introduction of a P249T amino acid substitution in the NS3 helicase of North Amercan strain NY99 led to a highly attenuated phenotype, whereas a T249P substitution introduced in a low-virulence WNV strain resulted in a phenotype highly virulent to American crows (22).
In certain cancer cells mutations/deletions are observed at G4s, if a helicase that is important for G4 unwinding is mutated.
Andrew Herr is the CEO of Mind Plus Matter, a human performance consulting firm, and Helicase, a technology consulting firm.
Werner's syndrome protein (WRN), a member of the RecQ helicase family, plays an important role in DNA ICL repair (Cheng et al.
The research findings described in this media release can be found in the Journal of Clinical Investigation Journal, under the title, "DEAD-box Helicase DP103 Defines Metastatic Potential of Human Breast Cancers" by Eun Myoung Shin 1,2, Hui Sin Hay 1,2,3, Moon Hee Lee 4, Jen Nee Goh 1,3, Tuan Zea Tan 1, Yin Ping Sen 5, See Wee Lim 5, Einas M.
Nucleic acid amplification-based molecular methods, such as PCR, RT-PCR, loop-mediated isothermal amplification (LAMP), helicase dependant amplification (HDA), and other similar techniques, derive their utility from their combination of high specificity for what they amplify (targets must anneal to amplification primers of some form in each of these methods) and their impressive amplification capacity.
Major driving factors of the global market includes increasing prevalence of infectious disease and cancer, promise for less expensive and better throughput in gene amplification using INAAT, and advent of novel technologies such as Loop-Mediated Isothermal Amplification (LAMP), Nucleic Acid Sequence Based Amplification (NASBA) and Helicase Dependent Amplification (HDA).
Whole genome "jumping libraries" of a prenatal sample identified a translocation breakpoint that disrupted chromodomain helicase DNA binding protein 7 (CHD7), a causal locus in the CHARGE syndrome (coloboma of the eye, heart defects, atresia of the choanae, retardation of growth and/or development, genital and/or urinary abnormalities, and ear abnormalities and deafness), otherwise unidentifiable with current screening technology, the knowledge of which assists with prenatal counseling (68).
Among the topics are dormant replication origins, break-induced DNA replication, the mini-chromosome maintenance replicative helicase, the spatial and temporal organization of DNA replication in bacteria and eukarya, DNA replication timing, replication-fork dynamics, sister chromatid cohesion, translesion DNA polymerases, rescuing stalled or damaged replication forks, genome instability in cancer, regulating DNA replication in plants, endoreplication, the archaeology of eukaryotic DNA replication, human mitochondrial DNA replication, whether human papillomavirus infections are warts or cancer, and adenovirus DNA replication.
The Role of a UvrD Helicase and the SOS Response in Pseudomonas syringae pv.
For example, a question that calls for a description of DNA replication should have key words in the response that include semiconservative mechanism, origin of replication, leading strand, lagging strand, and relevant enzymes such as helicase and DNA polymerase; these are some of the terms I would check for in the student's answer.