Hemagglutination


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Related to Hemagglutination: hemagglutination test, Hemagglutination Inhibition

hemagglutination

[‚hē·mə‚glüd·ən′ā·shən]
(immunology)
Agglutination of red blood cells.

Hemagglutination

 

the agglutination and subsequent precipitation of red blood cells, caused by hemagglutinins, bacteria, viruses, and agents capable of being adsorbed onto the surface of red blood cells.

Clusters of red blood cells, distinguishable to the naked eye as heaps, lumps, and clumps, are formed during hemagglutination. Hemagglutination is caused by the interaction of the agglutinogens present in red blood cells with plasma that contains agglutinins. Each agglutinogen has a corresponding agglutinin. The term “isohemagglutination” is used to designate the hemagglutination that takes place during the interaction of different blood groups in animals of the same species; “heterohemagglutination” is the term applied to the process in animals of different species. The laws of blood transfusion and identification of blood groups are based on the hemagglutination reaction. After the transfusion of incompatible blood, hemagglutination may occur in the bloodstream and cause severe (sometimes fatal) complications. In forensic medicine the hemagglutination reaction is used to determine the source of blood stains and as an additional test in cases of disputed paternity. In microbiology and immunology, the hemagglutination reaction is used to determine antiserum activity, for example, or type of virus. A distinction is made between active hemagglutination, which is caused by the direct action of an appropriate agent on the red blood cells, and passive hemagglutination, caused by a specific antiserum to the antigen previously adsorbed by the red blood cells. Hemagglutination may be caused by antibodies acting against one’s own red blood cells (auto-hemagglutination) or against red blood cells of the same species (homoagglutination) as well as by the polysaccharides of the causative bacteria of tuberculosis, plague, and tularemia, by the polysaccharides of the colon bacillus, and by the viruses of influenza, mumps, pneumonia of white mice, swine and horse influenza, smallpox vaccine, yellow fever, and other diseases.

KH. KH. PLANEL’ES and A. M. POLIANSKAIA

References in periodicals archive ?
Hemagglutination assays were performed using human (ABO groups), sheep and rat blood in a U-bottomed 96-well microtiter plate.
5) Careful serological investigations can shed light on the variation seen in hemagglutination, with some of these observations well documented by the manufacturer.
On the percentage inhibition of viral induced hemagglutination by the aqueous extract of Gynostemma pentaphyllum the 200 mg/mL (pre infection) gave the highest inhibition (85%) while the 2 mg/mL (pre infection) gave the lowest inhibition of 35%.
The protein shows the highest value of VNN hemagglutination then performed clinical tests on grouper for anti-protein antibodies VNN adhesion.
One hemagglutination unit is the reciprocal of the highest dilution of the lectin sample inducing hemagglutination.
Historically, serological assays for detecting antibodies that inhibit influenza virus hemagglutination or that neutralize infection in vitro were used to diagnose influenza virus infection in patients.
SAN FRANCISCO--Compared with standard dose inactivated influenza vaccine, high-dose influenza vaccine produced noninferior hemagglutination inhibition titer responses for all A/H1N1, A/H3N2, and B influenza strains among frail elderly long-term care residents in a randomized study conducted during the 2011-2012 and 20122013 influenza seasons.
The results from a study in mice demonstrated that Inovio's vaccine generated not only hemagglutination inhibition (HAI)-based protection against the H7N9 virus but also strong T-cell responses.
It was also found that the Multimeric-001, when used in conjunction with a commercially available strain-dependant seasonal influenza vaccine (trivalent inactivated vaccine, or TIV), enhances the performance of the TIV by increasing the rates of Hemagglutination Inhibition (HI) seroconversion to influenza strains both included, and not-included, in the TIV itself.
Immunogenicity data from prelicensure clinical trials showed that people aged 65 and older who received the high-dose vaccine had significantly higher hemagglutination inhibition titers against all three influenza virus strains, compared with the standard-dose Fluzone vaccine.

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