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Related to Heparin-induced thrombocytopenia: thrombin, disseminated intravascular coagulation


The condition of having an abnormally small number of platelets in the circulating blood.



a decrease in the number of platelets to fewer than 200,000 per mm3 in the peripheral blood. It may result from the redistribution of platelets in the bloodstream or from hemorrhage. Other causes are the intensified loss of platelets associated with thrombocytopenic purpura, splenomegaly, disseminated intravascular thrombosis, and the use of certain drugs. Thrombocytopenia may also result from disturbance of platelet formation in the bone marrow in leukemia or aplastic anemia, and from ionizing radiation. Blood clotting is impaired in thrombocytopenia, resulting in a tendency of the mucous membranes to bleed, as well as in hemorrhaging and the appearance of petechiae in the internal organs. Bleeding usually becomes continuous when the platelet count falls below 20,000–30,000 per mm3 of blood. Therapy involves treatment of the underlying disease, administration of hemostatics, and transfusion of platelets.

References in periodicals archive ?
A spontaneous prothrombotic disorder resembling heparin-induced thrombocytopenia.
Diagnostic testing for heparin-induced thrombocytopenia (HIT): an enhanced platelet factor 4 complex enzyme linked immunosorbent assay (PF4 ELISA).
Physicians should be alert to the possibility of heparin-induced thrombocytopenia, as a delay in diagnosis can result in serious morbidity or mortality.
Cutaneous dalteparin reactions associated with antibodies of heparin-induced thrombocytopenia.
There are 2 types of heparin-induced thrombocytopenia (HIT).
It does not have a risk for thrombocytopenia or heparin-induced thrombocytopenia, is relatively short-acting, and is easy to monitor.
Similarly, the acquired conditions, lupus anticoagulants, and heparin-induced thrombocytopenia have a strong association with cerebrovascular disease.
Enoxaparin also has a lower incidence of heparin-induced thrombocytopenia than UFH.
Angiomax is also indicated in patients with, or at risk of, heparin-induced thrombocytopenia and thrombosis syndrome (HIT/HITTS) undergoing PCI.

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