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TPN
(redirected from Hepatic dysfunction)

   Also found in: Dictionary/thesaurus, Medical, Wikipedia 0.04 sec.
TPN, in biochemistry, abbreviation for triphosphopyridine nucleotide, a coenzyme biotin, is a member of the B complex; it was first isolated in 1935 from dried egg yolk, and its structure was established in 1942. Biotin is usually found attached to a lysine residue in certain enzymes, where it participates in reactions involving the transfer of carboxyl
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 now usually called nicotinamide adenine dinucleotide phosphate, or NADP.
TPN


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Clinical features and complications of Alstrom syndrome Patient Presentation (*) Literature, % in the present study Retinal degeneration 98 + Sensorineural deafness 89 + Diabetes 82 + Obesity 98 - Acanthosis nigricans 68 + Hypergonadotropic 78 + hypogonadism Hypothyroidism 17 - Short stature 98 + Hepatic dysfunction 92 + Dilated cardiomyopathy 60 + Renal dysfunction 49 + *- 1.
In cirrhosis, hepatic dysfunction and sinusoidal portal pressure probably both send a message to the kidney to retain excess sodium and fluid, while the portal hypertension serves to localize excess fluid to the peritoneal cavity rather than the periphery.
It has also been suggested that chemotherapy agents may be administered without dose reduction if there is no renal, haematological or hepatic dysfunction [5, 6].
 
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