hepatocyte

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hepatocyte

[hə′pad·ə‚sīt]
(histology)
An epithelial cell constituting the major cell type in the liver.
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References in periodicals archive ?
We're excited to expand our product offering with a complete hepatocyte differentiation system that can allow the creation of large panels of hiPSC-derived hepatocytes with specific genotypes/phenotypes, providing an ideal solution for disease modeling, in vitro drug discovery, drug metabolism, and toxicology-related studies.
Genetically corrected mutant hIPSCs differentiated into hepatocytes have been used as cell therapy in animal models of inherited metabolic disorders but direct infusion of hepatocytes into the liver is unlikely to achieve polarised bile flow and correct ICDs.
In addition, we also preliminarily evaluated the rabbit antiGH polyclonal antibodies to determine whether these polyclonal IgG antibodies contain neutralising antibodies that can inhibit GH binding to the GHR expressed on porcine hepatocytes or CHO-GHR cells.
Kenneth Brouwer, CSO for Qualyst Transporter Solutions said: “We are looking forward to working with Solvo to offer B-CLEAR[R] technology and Transporter Certified[TM] human hepatocytes to their customers in Europe and Asia.
In the article 'Generation of Functional Hepatocyte-Like Cells from Human Pluripotent Stem Cells in a Scalable Suspension Culture' the authors describe the method used for scale-up, differentiation of the pluripotent stem cells into liver cells, and characterization and purification of the hepatocytes based on their physiological properties and the expression of liver cell biomarkers.
This model was compared to human liver cells from deceased donors and found to be equivalent, suggesting that stem cell-derived hepatocytes have potential to improve the preclinical assessment of liver toxicity," said Anthony Atala, MD, director of the Wake Forest Institute for Regenerative Medicine, and Editor of STEM CELLS Translational Medicine.
One case report of predominantly centrilobular damage in a patient treated with AZA describes a different pattern of injury, with centrilobular cholestasis, focal feathery degeneration, and occasional ground-glass hepatocytes.
Here we report about the effect of an ethanolic extract from GP on FFA-dependent cell death, oxidative stress, and lipid accumulation in hepatocytes of a primary cell culture from rat liver.
Allameh called "optimization of culture medium and proliferation conditions, cells differentiation in vitro, and providing conditions for increasing the resistance and maintenance of hepatocytes evolved from stem cells" as the results of this research project.
Paracetamol 300 [micro]g/mL was used to produce submaximal toxicity in isolated rat hepatocytes.
Cell death of hepatocytes and endothelial cells during reperfusion is characterized by swelling of cells and their organelles, release of cell contents, eosinophilia, karyolysis, and induction of inflammation [1].

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