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heterocyclic compound
(redirected from Heterocyclic amines)

   Also found in: Wikipedia 0.10 sec.

heterocyclic compound

Any of a class of organic compounds whose molecules contain one or more rings of atoms with at least one atom (the heteroatom) being an element other than carbon, most frequently oxygen, nitrogen, or sulfur. As in regular cyclic hydrocarbons, such heterocyclic rings may include single, double, or triple bonds or be aromatic (see covalent bond; aromatic compound), and the compound may contain one or more single rings or have fused rings (in which adjoining rings share two carbon atoms). Compounds having five-membered heterocyclic rings include chlorophyll, hemoglobin, indigo, tryptophan, and certain polymers. Those with six-membered heterocyclic rings include pyridine, pyridoxine (vitamin B6; see vitamin B complex), vitamin E, quinine, and the pyran nucleus, which is found in sugars and the anthocyanin pigments. Nicotine and morphine have both five- and six-membered heterocyclic rings; some antibiotics (e.g., penicillin) have two different heteroatoms in their rings. Other important heterocyclic compounds are pyrimidines, which occur in barbiturates, and purines, which occur in caffeine and related compounds; pyrimidine and purine are the parent compounds of the nucleic acids.



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Polyaromatic hydrocarbons (PAHs) and heterocyclic amines (HCAs) are carcinogens in the food supply, but as food items not implicated in the aetiology of colorectal cancer may actually be greater contributors to the total dietary intake of these compounds than red meat, they do not provide a plausible basis for implicating red meat in carcinogenesis.
Second, the grilling of meat can form two kinds of potentially carcinogenic compounds: polycyclic aromatic hydrocarbons (PAHs) and heterocyclic amines (HCAs).
Heterocyclic amines are documented mutagens and carcinogens in animal models (Nagao and Sugimura 2000; Weisburger 2002), and for which there is human evidence not only of several types of high-incidence cancers, such as colon, breast, and prostate, but which also affect the heart muscle (Butler et al.
 
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