Hammerhead ribozymes, as based on the Haseloff and Gerlach model (Nature, 1988), consist of a catalytic core made up of a highly conserved sequence
of 24 nucleotides that cleave substrate RNAs.
Our genomic imprinting study focused on highly conserved sequence
characteristics in the set of particular species being studied.
These reagents contain shorter highly conserved sequence
regions improving assay specificity, and the probes are non-cleavable which allows post-PCR melt curve analysis.
A DNA microarray with highly conserved sequences
from >1,000 viruses was selected to screen for known and novel viruses (3).
The partial 3D regions of all 6 bovine kobuviruses exhibited highly conserved sequences
Because primers are designed using highly conserved sequences
, the ITS primers will likely amplify in all oyster species and hence provide possible detection and identification of new or unknown species.
The compound consists of multiple individual, chemically modified, siRNA sequences which target highly conserved sequences
in the Hepatitis C viral genome.