AMPAR-mediated synaptic transmission in the CA1 hippocampal region
of neonatal rats: Unexpected resistance to repeated ethanol exposure.
John Woodard and his colleagues performed five tests on 78 healthy elders: a structural MRI (sMRI) that measures the size of the hippocampal region
of the brain; a functional MRI (fMRI) that shows how the brain is activated during mental tasks; a blood test that identifies the APOE e4 allele (a known genetic marker for Alzheimer's disease); and two standard neuropsychological tests that measure mood and ability.
These EEG findings show that the hippocampal region
is, indeed, where a significant change in brain wave activity is taking place in patients on active therapy, and corroborates our theory that NSI-189 targets the hippocampus.
The researchers examined three sub-regions of the hippocampus region- CA1, CA3 and the dentate gyrus area of the hippocampal region
called CA23DG (CA stands for cornu ammonis).
In the study presented at the SFN annual meeting, SPC9766 reduced the neuronal cell death observed in the hippocampal region
of the brain and the severity of seizures in an epilepsy model.
In post-MD training at Stanford, he has focused on affective disorders, studied the hippocampal region
of schizophrenic and depressed patients, and has been published in the Proceedings of the National Academy of Science.
Extent of cell damage in CA1 hippocampal regions
was quantified as the mean number of the persisting neurons in the coronal sections.
Then the investigators exposed the yeast Candida albicans, a major cause of meningitis, to tissue from the hippocampal regions
of brains from people who had died of Alzheimer's and from people of the same age who did not have dementia when they died.