There are several reports in literature linking HLA antigens
and sarcoidosis, which is a granulomatous disease of unknown etiology.
Table 1 Sample HLA typing test results Mother HLA-A2, A11; B35, B62 Cultured fetal cells HLA-A2, A11; B35, B51 Obligate paternal HLA-A2 or 11; B51 (not found HLA antigens
Three pairs of HLA antigens
are compared between donor and patient.
Hashimoto H, Nishimura Y, Dong RP, et al: HLA antigens
in Japanese patients with systemic lupus erythematosus.
The conventional way to test for tissue compatibility is to obtain a blood sample and test it against a set of antibodies that react to HLA antigens
Several HLA antigens
are associated with various diseases, and probably the strongest association known is that between the HLA-B27 antigen and rheumatic diseases such as ankylosing spondylitis (also known as Bechterew disease), Reiter syndrome, and acute anterior uveitis .
Physicians have known for years that apatient with HLA antibodies specific to a donor's HLA antigens
is much more likely to reject that donor's transplanted organ.
In conjunction with the Diego screening study, we plan to begin HLA typing to correlate disease to various HLA antigens
A clinical study demonstrated high correlation and superior reproducibility when CROSS-STAT was compared to microlymphocytotoxicity for detection of donor specific antibodies to recipient HLA antigens
1 Part 1 - gradual delivery of diagnostic kits for the study of class I HLA antigens
(locus A, B, C) and class II (DR and DQ locus) at a low resolution by SSP.
The cells are readily available in cord blood banks, are routinely typed for HLA antigens
and ABO blood groups, and are tested for infectious agents," she said.
Dausset's discovery and continued work with the HLA antigens
has permitted physicians to select organ donors by matching as closely as possible the HLA molecules of donor and recipient to reduce the risk of graft rejection.