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Hodgkin’s disease, a condition characterized by granulomas of the lymph nodes, first described in 1832 by the English physician T. Hodgkin.

The cause of lymphogranulomatosis has not been established. It has been speculated that its origin is viral; the influence of genetic, blastomogenic, or auto-aggressive factors is also possible. The disease may affect persons of any age, but it is chiefly found in the young (under 40). Usually, one group of lymph nodes (axillary, cervical, mediastinal, retroperitoneal, or mesenteric) is affected initially. Gradually spreading, the lymphogranulomatosis then begins to attack all of the lymph nodes, as well as organs, including the lungs, bones, and skin.

In accordance with the generally accepted International Clinical Classification of Lymphogranulomatosis (1965), four stages are distinguished in the course of the disease: the first, or localized, stage involves one or two adjacent regions of nodes; the second, or regional, stage involves two or three nonadjacent regions of nodes on one side of the diaphragm (that is, either in the thoracic cavity or in the abdominal cavity); the third, or generalized, stage involves only the lymphatic system, on both sides of the diaphragm (lymph nodes, spleen, tonsils, Waldeyer’s ring); the fourth, or disseminated, stage involves the entire lymphatic system, in combination with affection of the viscera (lungs, pleura, liver, kidneys, bone marrow, bones), soft tissues, and skin. The affected lymph nodes characteristically contain giant cells, or Berezovskii-Sternberg cells (first described by the Russian physician S. Ia. Berezovskii in 1890).

Lymphogranulomatosis is characterized by periodic fever (sometimes wavelike), general weakness, abundant sweating, itching, phenomena associated with pressure by the enlarged mediastinal lymph nodes on the neighboring organs, cough, dyspnea, dilatation of the veins, and edema of the face and neck. When the retroperitoneal nodes are affected there is also distention of the abdomen, diarrhea, and pain. Anemia and moderate leukocytosis develop, and the hemogram changes. The erythrocyte sedimentation rate (ESR) rises sharply (to 60–80 mm per hour). The course of the disease and its prognosis depend greatly on the form of the disease, the time of diagnosis, and the treatment used.

Treatment is conducted in specialized dispensaries and on-cohematological clinics. Radiation therapy (distance gamma-therapy) entails high-dose irradiation of the foci of the condition and prophylactic irradiation of the lymphatic zones to which the process may spread. Surgical treatment involves removal of the affected focus in combination with irradiation. Antitumoral cytostatic agents, antitumoral antibiotics, and hormonal therapy are also used.


Kurdybailo, F. V. Limfogranulomatoz, 2nd ed. Leningrad, 1971. (Bibliography, pp. 128–142.)
Kraevskii, N. A., N. M. Nemenova, and M. P. Khokhlova. “Limfo-granulomatoz.” In the collection Patologicheskaia anatomiia i voprosy patogeneza leikozov. Moscow, 1965. Pages 228–236.
Larionov, L. F. Khimioterapiia zlokachestvennykh opukholei. Moscow, 1962.
References in periodicals archive ?
Lymph node histology revealed a pleomorphic infiltrate with Reed-Sternberg-like cells suspicious for Hodgkin disease.
It is striking that the histology depicted in the photomicrograph from this case very closely resembles lymphocyte-predominance Hodgkin disease and that the authors stated that the histology was "morphologically most similar to a Hodgkin's sarcoma but without any definite Reed-Sternberg cells.
Our patient was diagnosed with Hodgkin disease involving the mesenteric lymph nodes recovered from a right hemicolectomy for colonic adenocarcinoma.
Hodgkin disease infrequently presents below the diaphragm, and its occurrence in elderly males is more common in these sites.
He had no evidence of disease at last follow-up, 8 months after the diagnosis of Hodgkin disease.
Primary gastrointestinal Hodgkin disease in association with Crohn disease is a rare entity.
A mediastinoscopy with lymph node biopsy was performed and showed Hodgkin disease, nodular sclerosis type.
The association of Hodgkin disease and tuberculosis is not uncommon.
Hodgkin disease is a lymphoma with a bimodal peak incidence occurring in the ages between 15 and 34 years, and 55 years and older.
Traditionally, Hodgkin disease has been divided into 4 subtypes based on differences in the appearance of the neoplastic cells, as well as the components of the background.