PML-RAR[alpha] can heterodimerize with RXR or form homodimers
and subsequently binds to RARE, located in the promoters of the ATRA-responsive target genes.
HERmark(TM), our recently launched breast cancer assay, is bringing new options to breast cancer patients with quantitative measurements of HER2 total protein and HER2:HER2 homodimer
San Francisco, CA) announced that scientific collaborators have presented additional clinical results on HERmark, the company's novel oncology assay, as a means to measure HER2 total protein and homodimer
levels and predict response to Herceptin (trastuzumab) in patients with metastatic breast cancer at the 44th ASCO Annual Meeting taking place in Chicago, Illinois.
12) Interestingly, Erk inhibitors actually enhanced the translocation of p50, suggesting that Erk inhibition enhances the binding of p50/p50 homodimers
to nuclear DNA.
A new test to measure total HER2 as well as HER2 homodimers
and heterodimers is also available as a predictor for efficacy of anti-HER2 therapies.
The transcriptional regulation of individual subunits influences the range of GST homodimers
and heterodimers formed.
Introduction at ASCO of a Collaborative Biomarker Study, designed to (i) compare conventional IHC and FISH methods of HER2 testing with the quantitative measurements of HER2 total protein and HER2 homodimers
provided by HERmark, and (ii) to describe the expression/co-expression profiles identified by Monogram's HER1 and HER3 Total Protein Assays along with HER2 total protein and homodimer
levels identified by HERmark to facilitate analyses of how such measurements may correlate with certain laboratory and clinical parameters, including disease progression.
Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers
Bcl-2 and Bax regulate apoptosis by forming homodimers
Members of this family of proteins code for basic helix-loop-helix/leucine zipper (BHLH-LZ) transcription factors that bind to the consensus hexanucleotide E-box sequence CA[C/T]GTG, either as homodimers
The patents are broad and relate to the use of Monogram's VeraTag technology for methods of detecting and profiling protein complexes, including protein homodimers
The haptoglobin molecules synthesized in Hp2-1 heterozygous people are assembled into linear homodimers
and multimers from various numbers of [alpha]2[beta] subunits flanked by 1 [alpha]1[beta]subunit at each terminus (86-300 kDa) (11).