dimer

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Related to Homodimers: dimeric, Heterodimerization, Homodimeric

dimer

Chem
a. a molecule composed of two identical simpler molecules (monomers)
b. a compound consisting of dimers

dimer

[′dī·mər]
(chemistry)
A molecule that results from a chemical combination of two entities of the same species, for example, the chlorine molecule (Cl2) or cyanogen (NCCN).
References in periodicals archive ?
HERmark(TM), our recently launched breast cancer assay, is bringing new options to breast cancer patients with quantitative measurements of HER2 total protein and HER2:HER2 homodimer.
San Francisco, CA) announced that scientific collaborators have presented additional clinical results on HERmark, the company's novel oncology assay, as a means to measure HER2 total protein and homodimer levels and predict response to Herceptin (trastuzumab) in patients with metastatic breast cancer at the 44th ASCO Annual Meeting taking place in Chicago, Illinois.
12) Interestingly, Erk inhibitors actually enhanced the translocation of p50, suggesting that Erk inhibition enhances the binding of p50/p50 homodimers to nuclear DNA.
A new test to measure total HER2 as well as HER2 homodimers and heterodimers is also available as a predictor for efficacy of anti-HER2 therapies.
The transcriptional regulation of individual subunits influences the range of GST homodimers and heterodimers formed.
Introduction at ASCO of a Collaborative Biomarker Study, designed to (i) compare conventional IHC and FISH methods of HER2 testing with the quantitative measurements of HER2 total protein and HER2 homodimers provided by HERmark, and (ii) to describe the expression/co-expression profiles identified by Monogram's HER1 and HER3 Total Protein Assays along with HER2 total protein and homodimer levels identified by HERmark to facilitate analyses of how such measurements may correlate with certain laboratory and clinical parameters, including disease progression.
Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers.
Members of this family of proteins code for basic helix-loop-helix/leucine zipper (BHLH-LZ) transcription factors that bind to the consensus hexanucleotide E-box sequence CA[C/T]GTG, either as homodimers or heterodimers.
The patents are broad and relate to the use of Monogram's VeraTag technology for methods of detecting and profiling protein complexes, including protein homodimers and heterodimers.
The haptoglobin molecules synthesized in Hp2-1 heterozygous people are assembled into linear homodimers and multimers from various numbers of [alpha]2[beta] subunits flanked by 1 [alpha]1[beta]subunit at each terminus (86-300 kDa) (11).