Homeostasis (redirected from Homostasis)

homeostasis

Any self-regulating process by which a biological or mechanical system maintains stability while adjusting to changing conditions. Systems in dynamic equilibrium reach a balance in which internal change continuously compensates for external change in a feedback control process to keep conditions relatively uniform. An example is temperature regulation—mechanically in a room by a thermostat or biologically in the body by a complex system controlled by the hypothalamus, which adjusts breathing and metabolic rates, blood-vessel dilation, and blood-sugar level in response to changes caused by factors including ambient temperature, hormones, and disease.

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Homeostasis

The relatively constant conditions within organisms, or the physiological processes by which such conditions are maintained in the face of external variation.

Similar homeostatic controls are used to keep factors such as temperature and blood pressure nearly constant despite changes in an organism's activity level or surroundings. Such systems operate by detecting changes in the variable that the system is designed to hold constant and initiating some action that offsets any change. All incorporate a sensor within the system that responds when the actual condition differs from the desired one, a device to ensure that any action taken will reduce the difference between actual and desired, and an effector to take the needed action as directed. The crucial aspect is that information is fed back from effector to sensor and action is taken to reduce any imbalance—hence the term negative feedback.

Blood pressure is, at least on a moment-to-moment basis, regulated by a system for which the sensors are stretch-sensitive cells located in the neck arteries that carry blood from heart to brain. An increase in blood pressure triggers sensor activity; their signal passes to the brain; and, in turn, the nerve supplying the heart (the vagus) is stimulated to release a chemical (acetylcholine) that causes the heart to beat more slowly—which decreases blood pressure.

The volume of the blood is subject to similar regulation. Fluid (mainly plasma) moves between the capillaries and the intercellular fluid in response to changes in pressure in the capillaries. A decrease in blood volume is detected by sensors at the base of the brain; the brain stimulates secretion of substances that cause contraction of tiny muscles surrounding the blood vessels that lead into the capillaries. The resulting arteriolar constriction reduces the flow of blood to, and the pressure within, the capillaries, so fluid moves from intercellular space into capillaries, thus restoring overall blood volume.

Body temperature in mammals is regulated by a sensor that consists of cells within the hypothal­amus of the brain. Several effectors are involved, which vary among animals. These include increasing heat production through nonspecific muscle activity such as shivering; increasing heat loss through sweating, panting, and opening more blood vessels in the skin (vasodilation); and decreasing heat loss through thickening of fur (piloerection) and curling up. Humans sweat, but they retain only a vestige of piloerection (“goose flesh”). See Thermoregulation

While the homeostatic mechanisms described involve the neural and endocrine systems of mammals, it is clear that such arrangements pervade systems from genes to biological communities, and that they are used by the simplest and the most complex organisms.

Organisms of every kind develop, mature, and even shift physiological states periodically—between day and night, with seasons, or as internal rhythms. Thus organisms cannot be considered constant except over short periods. However, all such changes appear to involve the same basic sensing of the results of the past activity of the system and the adjusting of future activity in response to that information. Development of an organism from a fertilized egg is far from a direct implementation of a genetic program; probably no program could anticipate all the variation in the external context in which an organism must somehow successfully develop. See Biological clocks, Nervous system (vertebrate)