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homeobox [′hō·mē·ə‚bäks]
(cell and molecular biology) A highly conserved sequence of deoxyribonucleic acid (DNA) that occurs in the coding region of development-controlling regulatory genes and codes for a protein domain that is similar in structure to certain DNA-binding proteins and is thought to be involved in the control of gene expression during morphogenesis and development. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
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No references found | Describing their work in the online edition of the Proceedings of the National Academy of Science, lead researchers Robb Krumlauf and Leanne Wiedemann have revealed that they wanted to understand the "instruction manual" for a Hox gene, which tells the early brain which genes to turn on, and in what order, to specify critical regions of the adult brain. Branchial HOX gene expression and human craniofacial development. For example, aldehyde oxidase (probably identical to retinaldehyde oxidase) irreversibly converts retinaldehyde to retinoic acid, which mediates hematopoiesis and progenitor cell differentiation through its effects on Hox gene expression during embryogenesis (Look 1997; Tocci et al. |
Hox gene |
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