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homeobox |
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homeobox [′hō·mē·ə‚bäks] (cell and molecular biology) A highly conserved sequence of deoxyribonucleic acid (DNA) that occurs in the coding region of development-controlling regulatory genes and codes for a protein domain that is similar in structure to certain DNA-binding proteins and is thought to be involved in the control of gene expression during morphogenesis and development. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Ultimately, a set of eight of these Hox genes was identified in Drosophila, and a homologous but expanded set of 13 Hox genes also was identified in mammals. Leckman's group is currently investigating possible effects of other Hox genes on OCD. Mice, it turns out, have 4 clusters of Hox genes, which are laid out in the same head-to-tail way as they are in the fruit fly. |
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