In addition, miR-885-5p was found to be a specific marker for Hurthle cell carcinoma
in tissue materials, as its upregulation was identified in 15 of 17 (88%) of the Hurthle cell carcinomas
, but in only 1 of 21 (4.
This conclusion does not mean to imply that follicular and Hurthle cell carcinomas
smaller than 1 cm do not exist, nor that the cytologic features of these tumors when they are smaller than 1 cm are any different than when they are greater than 1 cm; they do exist and they are not different.
Prognostic factors of recurrence in encapsulated Hurthle cell carcinoma
of the thyroid gland: a clinicopathologic study of 50 cases.
of Cases Hyperplastic nodule 1 Goiter 4 Adenoma 3 Hurthle cell adenoma 5 PTC, usual 14 PTC, solid 2 PTC, Warthin-like 1 PTC, follicular variant 15 PTC, tall cell 5 PTC, columnar 1 PTC, diffuse sclerosing 2 PTC, microcarcinoma 2 Metastatic PTC 3 Follicular thyroid carcinoma 3 Hurthle cell carcinoma
8 Poorly differentiated carcinoma 1 Anaplastic carcinoma 2 Insular carcinoma 2 Medullary thyroid carcinoma 1 * PTC indicates papillary thyroid carcinoma.
Age, y/Sex Histologic Findings 1 12/F Papillary hyperplastic thy- roid nodule 2 15/F Papillary hyperplastic thy- roid nodule; incidental minimally invasive Hurthle cell carcinoma
3 11/M Papillary hyperplastic thy- roid nodule
Fine-Needle Aspirate (FNA) Diagnoses Using Conventional Criteria and Follow-up Histopathologic Diagnoses FNA Diagnosis (n) Surgical Follow-up (n) Hurthle cell neoplasm (13) Hurthle cell adenoma (6) Hurthle cell carcinoma
(3) Hashimoto's thyroiditis (4) Nonneoplastic thyroid (17) Hurthle cell carcinoma
(1) Hashimoto's thyroiditis (12) Nodular goiter (4)
of Cytologic Diagnosis Histologic Diagnosis Cases Negative: NOS(*) Papillary carcinoma 5 Negative: follicular adenoma Well-differentiated 1 follicular carcinoma Negative: Hashimoto thyroiditis Follicular variant of 1 papillary carcinoma Negative: adenomatous nodule Follicular variant of 2 papillary carcinoma Hurthle cell carcinoma
1 Follicular carcinoma 1 (*) NOS indicates not otherwise specified.
The lung nodule excision demonstrated metastasis from the Hurthle cell carcinoma
Since neither the architectural nor the cytologic grades influenced survivals among cases of follicular, papillary, or Hurthle cell carcinoma
groups (vide infra), for the purpose of this study, all insular carcinomas and other tumors with insular carcinoma-like foci (regardless of the cytologic features) were regarded as poorly differentiated tumors, as were the cases of the tall cell variant of papillary carcinoma.
Ultrastructural examination supported this hypothesis, showing that neoplastic cells of the mucinous area were very rich in mitochondria and suggesting that this component could be considered as a mucinous differentiation of the Hurthle cell carcinoma
This pseudopapillary pattern can be mistaken for a papillary Hurthle cell carcinoma
, which can alter the clinical management since Hurthle cell carcinomas
behave in a more aggressive fashion than do papillary carcinomas.
Follicular and Hurthle cell carcinomas
, with their angioinvasive features, are more common culprits than is papillary carcinoma.