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hybridoma
(redirected from Hybridomas)

   Also found in: Medical, Wikipedia 0.06 sec.
hybridoma [‚hī·brə′dō·mə]
(immunology)
A hybrid myeloma formed by fusing myeloma cells with lymphocytes that produce a specific antibody; the individual cells can be cloned, and each clone produces large amounts of identical (monoclonal) antibody.


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Studies suggest that T-cell hybridomas derived from the T-cells of patients with MCD produce a molecule known as glomerular permeability factor (GPF).
In 2003, two murine hybridomas, clones 3C2 and 38G6, secreting specific monoclonal antibodies (MAb) to allergens derived from the American cockroach, Periplaneta americana, were produced in our laboratory (Sookrung et al.
Hybridomas were selected in hypoxanthineaminopterin-thymidine medium and maintained in vitro by methods modified from Van Deusen (1983) in Dulbecco's modified Eagle's medium supplemented with 15% horse serum (Sigma).
 
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