haloalkane

(redirected from Hydrofluoroalkane)
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haloalkane

[¦ha·lō¦al‚kān]
(organic chemistry)
Halogenated aliphatic hydrocarbon.
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References in periodicals archive ?
A Post-hoc Responder Analysis of Improvement in Symptoms Following Treatment with Ciclesonide Hydrofluoroalkane Nasal Aerosol in Patients with Seasonal and Perennial Allergic Rhinitis (Poster #667)
Inhaled corticosteroids (ICS) at low to medium doses (<1500 mcg beclomethasone hydrofluoroalkane per day) for asthma and chronic obstructive pulmonary disease (COPD) don't increase the risk of significant bone loss or fracture at 2 to 3 years follow-up (strength of recommendation [SOR]: A, systematic reviews and randomize controlled trials [RCTs]).
The company said that it will primarily use the funding to complete the Phase IIb clinical programme for its lead product, PT003, a combination bronchodilator comprised of glycopyrrolate, a long-acting muscarinic antagonist (LAMA), and formoterol, a well-known, long-acting B2-agonist (LABA), delivered via a hydrofluoroalkane metered dose inhaler (MDI) for the treatment of patients with COPD.
The new report will help ensure that the FDA has an adequate scientific basis to review inhaler applications that use an alternative, hydrofluoroalkane.
However, the hydrofluoroalkane (HFA)-propelled drug penetrates deeper into the lower lung, which causes a greater peak in plasma concentrations.
Levalbuterol (Xopenex), containing only the therapeutically active R-isomer of albuterol, is available in a nebulizer solution; an inhalation aerosol in a metered-dose inhaler, formulated with a nonchlorofluorocarbon propellant called hydrofluoroalkane (HFA), was approved in March but is not expected to be available until the end of this year.
Some of the new inhalers use hydrofluoroalkane, an environmentally friendly propellant, while others boast a "breath-activated" design, which requires a sharp, quick inhalation, as opposed to the slow, deep intake of the old inhalers.
An Evaluation of the Effect of Ciclesonide Hydrofluoroalkane Nasal Aerosol on Hypothalamic Pituitary Adrenal Axis in Pediatric Patients with Perennial Allergic Rhinitis (Poster #336) The HPA axis trial was designed as a randomized, placebo-controlled, double-blind clinical study that enrolled 89 patients 6 to11 years of age with a 1 year history of PAR.
Comment: In response to concerns about chlorofluorocarbons (CFCs) depleting the ozone layer, the new formulation of Atrovent contains the propellant hydrofluoroalkane (HFA).
CFC, chlorofluorocarbon; HFA, hydrofluoroalkane, DPI, dry-powder inhaler; MDI, metered-dose inhaler.
It is administered as a nonaqueous or "dry" spray delivered by hydrofluoroalkane (HFA), an environmentally friendly propellant.
Hydrofluoroalkane (HFA) is the replacement propellant heir apparent to CFCs, getting the thumbs up from environmentalists and physicians.