Delayed graft function in patients following hand-assisted laparoscopic donor nephrectomy and open living-donor nephrectomy Donor nephrectomy Hand-assisted laparoscopic donor nephretcomy (n = 35) * Delayed graft function [1 (3%)] Ruptured kidney (1) Open living-donor nephrectomy (n = 65) ** Delayed graft function [5 (8%)] Postoperative bleeding (2) Hyperacute rejection
(1) Infarction in the kidney (1) Ureteric obstruction (1) Postoperative bleeding (2)
occurs within minutes to hours after the release of the vascular clamps to the transplanted kidney.
Once past hyperacute rejection
, the organ must survive a secondary acute rejection--"delayed xenograft rejection"--that occurs within several days.
Genetic engineers are producing organs that include a human gene that shuts down the process of hyperacute rejection
We will remove, for example, complement activation factors that are on the surface of the endothelial cells and are stimulants to hyperacute rejection
Knocking out the gene responsible for attaching this sugar residue could greatly reduce the hyperacute rejection
of such transplanted organs.
We have overcome hyperacute rejection
, but we want to maintain that organ for at least an amount of time that would be considered acceptable.
All humans have preformed antibodies to pig tissue, which would lead to hyperacute rejection
of the transplanted xenograft.
These studies pinpoint whether the immune system has been sensitized, and predict the possibility of hyperacute rejection
of the transplanted kidney.
Gal transferase is responsible for synthesis of the cell-bound sugars that are targets of rejection by the human immune system, and are now believed to be largely responsible for the phenomenon of hyperacute rejection
of animal organs transplanted into human recipients (xenotransplants).
is a rare complication of liver transplantation, as is portal vein thrombosis.