2008) demonstrated that exposed individuals with hyperkeratosis
have significantly higher DNA damage (measured by a chromosomal aberration assay in lymphocytes) and less DNA repair capacity (measured using a challenge assay in whole blood) than those without skin lesions.
DiGiovanna JJ, Bale SJ: Clinical heterogeneity in epidermolytic hyperkeratosis
Papillon-Lefevre syndrome (PLS) is a rare autosomal recessive disorder presented with diffuse transgradient palmoplantar hyperkeratosis
, and an aggressive periodontal inflammation leading to premature loss of primary and permanent teeth.
, acantholysis, dyskeratosis, and suprabasilar clefts were also focally present.
Ulceration, as well as foci of hyperkeratosis
(thickening of the stratum corneum), may be seen within the areas of atrophy.
Sun-exposed epidermis becomes thickened as much as twofold compared to sun-protected skin and is disorganized, showing evidence of hyperkeratosis
, parakeratosis, and acanthosis.
Some patients have had hyperkeratosis
, psoriasis and eczema.
In this study, the most common adverse reactions (greater than or equal to 10%) of any grade for dabrafenib included hyperkeratosis
(thickening of the outer layer of the skin)(37%), headache (32%), pyrexia (fever)(28%), arthralgia (joint aches)(27%), papilloma (warts)(27%), alopecia (hair loss)(22%), palmar-plantar erythrodysesthesia (redness, swelling, peeling or tenderness of hands or feet)(20%), rash (17%), back pain (12%), cough (12%), myalgia (muscle aches)(11%), constipation (11%) and nasopharyngitis (cold-like symptoms)(10%).
Mild mucosal hyperplasia and hyperkeratosis
were observed within the crop, consistent with crop stasis, and the koilin layer was degenerative within the ventriculus.
Human exposure to inorganic arsenic, a potent oxidative stressor, causes various dermal disorders, including hyperkeratosis
and skin cancer.
1-3,6) Other findings include hyperkeratosis
and parakeratosis, pseudoepitheliomatous hyperplasia of the epidermis, and hyperplastic lymphoid tissue.
Histologic findings consist of hyperkeratosis
, acanthosis and marked decrease in dermal elastic fibers.