With regard to dermal effects, increased OGG1 expression showed increased risk of skin hyperkeratosis
in males, but the trend was not statistically significant in females.
The purpose of the present study was twofold: (1) to identify common characteristics or predisposing factors in patients with hyperkeratosis
, and (2) to determine the clinical significance and appropriate follow-up of hyperkeratosis
when it appears as the sole diagnosis on the Papanicolaou smear.
There is superficial hyperkeratosis
Cross sections of the tarsi showed moderate to severe orthokeratotic hyperkeratosis
, in some cases associated with Knemidocoptes species-like mites.
From these observations, it may be added that besides the size of amyloid deposition, prominent hyperkeratosis
, acanthosis and papillomatosis, other features like increased basal layer pigmentation and pigment incontinence (both more frequent in macular amyloidosis) as well as papillomatosis and periappendageal mononuclear and neutrophilic dermal infiltrate (more frequent in lichen amyloidosis) can be used for distinction between the two histologically.
The dermatological lesions appear first between the ages of 1 to 4 years and include palmoplantar keratosis, varying from mild psoriasiform scaly skin to overt hyperkeratosis
All of our healed grafts fared well as none of them developed marginal hyperkeratosis
for which non glabrous skin grafts are notorious and we had no incidence of graft contracture or subdermal fibrosis.
indicates large number of anucleated squamous cells present in Pap smear.
To our knowledge, there is no study that investigated genetic relationship between hyperkeratosis
with mastitis and milk yield.
Other skin lesions included footpad hyperkeratosis
, crusting, depigmentation, and erosions (Figure 2).
Other findings included hyperkeratosis
on the buccal, labial, and palatal mucosa, which created a thickened and nodular appearance.