EPS can be characterized as either hyperkinesias
(excessive movements) or bradykinesias (diminished movements):
10) They cited several clinical features that are highly suggestive of a malignant etiology: (1) single-branch palsy, (2) slow progression beyond 3 weeks, (3) no return of function at 6 months, (4) facial hyperkinesia
, especially hemifacial spasm, (5) associated cranial neuropathies, (6) recurrent ipsilateral paralysis, and (7) pain; some of these features were seen in our case.
By using stereotactic image-guided techniques, targets can be chosen to treat different symptoms: the ventrointermediate nucleus of thalamus for tremor; the internal globus pallidus for dyskinesia, dystonia, rigidity, akinesia, and tremor; and the subthalamic nucleus for all cardinal symptoms in advanced Parkinson's disease, including drug-induced hyperkinesia
(secondary to reduced drugs).
The child tolerated only a very gradual increase of medication, complicated by dose-dependent side effects, mainly hyperkinesia
The Company is also investigating the use of rotigotine CDS for treatment of Restless Legs Syndrome (RLS), an unpleasant hyperkinesia
of the legs that occurs primarily at night.