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Failure of a tissue or organ to achieve complete development.



or hypogenesis, underdevelopment of a tissue, organ, part of the body, or entire organism. Just as with aplasia, the basis of hypoplasia is impairment of the interuterine development of the fetus as a result of the effect of radiant energy on the mother’s organism, imbalance in nutrition, and certain infections transmitted from the mother to the fetus, such as German measles, toxoplasmosis, or poliomyelitis.

References in periodicals archive ?
In this group of patients, right lung hypoplasia is generally absent and the sign of "Turkish sword" can be determined more easily.
Deficiencies in magnesium can result in changes in ameloblasts and odontoblasts as well as hypoplasia of enamel and dentin.
Adams said he has seen cats and kittens like Tipsy with cerebellar hypoplasia before.
Josh was mainly affected by optic nerve hypoplasia," said Joanne.
These findings confirmed the initial clinical suspicions of a high percentage of fluoride-induced enamel hypoplasia (dental fluorosis) in the isolated island population of Brava.
Comparison of phenotype scores and rRNA and mRNA cleavage activities disclosed significant negative correlations between the degree of bone dysplasia and rRNA cleavage activity, between the degree of immunodeficiency or hematological abnormalities and mRNA cleavage activity, and between the incidence of hair hypoplasia and mRNA cleavage activity [52].
The disorder is characterised by agenesis (absence) or hypoplasia (underdeveloped) of the part of the brain called the cerebellar vermis and a malformed brain stem.
Poor prognostic factors are large size, rupture, cardiac abnormalities, respiratory distress at birth, pulmonary hypoplasia and co-morbid anomalies (Beckwith Weideman, Trisomy 13, 18 and 21, Pentalogy of Cantrell) (2-7).
Genes frequently involved in complex GKD include DMD, variations in which cause Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), and NR0B1 (DAX1), which is responsible for adrenal hypoplasia congenita (AHC) (2, 3).
The remaining malformations included midline defects, urogenital defects, cortical dysplasia, hypoplastic left heart syndrome, hypoplasia of the left ventricle, and diaphragmatic hernia with abdominal organ displacement.
Enamel hypoplasia results in a decreased quantitative enamel formation.