Bohnen NI, Gedela S, Herath P Constantine GM, Moore RY Selective hyposmia
in Parkinson disease: association with hippocampal dopamine activity.
, or poor sense of smell, can signal Parkinson's disease years before diagnosis.
This is considered rather severe hyposmia
and, interestingly, only about a third of these folks noticed that they even had this symptom.
Major Finding: Significantly more individuals with hyposmia
had DAT levels of 65% or lower, compared with normosmic individuals (11% vs.
While analysing 314 patients in the study, 71% of patients did not have any olfactory disturbance and 29% of patients were having olfactory disturbance, of which 4% of patients were having Anosmia and 25% of patients were having Hyposmia
The prevalence of hyposmia
or anosmia in PD has been reported to range from 70% to 90% .
The minor signs and symptoms are hyposmia
, fever, halitosis, headache, dental pain, cough, and otalgia.
Seven (10%) were having vague complaints especially irritation, pain or hyposmia
PD patients also suffer from a wide range of non-motor symptoms--including hyposmia
(poor sense of smell), gastroi ntestinal dysfunction, psychiatric features (e.
In addition to concerns regarding the efficacy of intranasal zinc therapy, increasing evidence indicates that this medication may be linked to severe, potentially permanent hyposmia
(reduced sense of smell) and anosmia (loss of smell)," the authors said.
Chronic rhinosinusitis (CRS) is defined as 12 weeks or more of two or more of the following symptoms: mucopurulent nasal drainage; nasal obstruction; facial pain, pressure, or fullness; hyposmia
and inflammation; nasal or middle meatus polyps; and/or imaging that shows sinus inflammation.
Kallmann syndrome is a genetic condition where the primary symptom is a failure to attain puberty and associated with additional symptoms of hypogonadism, hyposmia
or Anosmia and almost invariably infertility.