We have identified a new pathway, centered on IFN gamma, that controls the bone remodelling process both in-vivo and in-vitro.
We realised that this differentiation process involved IFN gamma-related genes, but also that these bone cells precursors could both be stimulated by IFN gamma and produced IFN gamma.
In the next step, the researchers focussed on an animal model where IFN gamma effect is blocked by inactivating its receptor-a model called IFN gamma receptor knock-out.
These findings confirm that IFN gamma is an integral factor for mesenchymal stem cells' differentiation into osteoblasts also in-vivo," said Kremer.
Both in-vitro and in-vivo results proved that IFN gamma was key to the differentiation of mesenchymal cells into bone cells, and to growth process of the bone.