interleukin-4

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interleukin-4

[‚in·tər′lük·ən ′fȯr]
(immunology)
A cytokine that is capable of a variety of activities, such as induction of proliferation by T cells, mast cells, megakarocytes, and erythroid precursors; induction of antibody secretion by B cells; and potentiation of the proliferation of mast cells. Abbreviated IL-4.
References in periodicals archive ?
We hypothesized that maternal exposure to airborne PAH may induce altered methylation status of the asthma genes IL4 and IFN[gamma].
In the thymus, we could not observe any significant different expression of IL4, IL-6 and IFN-[gamma] between the FR and CON group.
In human peripheral blood mononuclear cells in vitro, methylmercury concentrations of 100 [micro]g/L were capable of inducing Th2 cytokine production, whereas [gamma]-interferon production suppression occurred at 400 [micro]g/L; in this model, mercury chloride stimulated increases in IL4 only at 1,000 [micro]g/L (de Vos et al.
A total of 15 primer pairs were tested for amplification and sequencing of 13 candidate genes (PTH, CSF2, FOLR1, BDNF, LDHA, RPS13, ADM, CAT, WT1, FSHB, MYOD1, IL4 and ADRB2).
In addition, the first prospectively designed biologic agent developed for AD, a receptor blocker that influences IL4 and IL13, has been approved in adults with moderate to severe AD, and is already under study in children and adolescents.
En contraste el raton BALB/c es deficiente en IL-13, IL-4/13, o de los receptores cadena alfa de IL4 por lo que desarrolla una enfermedad cronica con una mayor carga parasitaria y una falla en la respuesta Th2 [20].
The third study identified lineage negative IL13 positive cells which were named innate helper type 2 cells (Ih2) using IL4 and IL13 reporter mice.
Genes that are related to complex diseases, like cytochrome P450 (CYP3A) [35], asthma (IL-13 [36], IL4 [37,38] and IL1A [39]), cardiovascular disease (matrix metallopeptidase 3 [MMP3] [40] and angiotensinogen [ACT] gene [41] type 2 diabetes calpain-10 [CAPN10] [36]) have also been reported to have signatures of selection.
Association of IL1 [beta] and IL4 gene polymorphisms with nasal polyps in a Polish population.
6) Local and systemic immunosuppression by activation of immunosuppressive molecules such as IL4, IL10, IL-1[beta], TNF-[alpha], and PGE2, or by alteration in cellular morphology, function or quantity of Langerhans cells and T lymphocytes (27,35-37), are other consequences of ROS production after UV-radiation exposure.
48) The abnormal T-cell populations in L-HES produce T helper 2 cytokines, including IL4, IL5, and IL13, and stimulate production of CCL17/TARC (thymus and activation-regulated cytokine); however, testing for production of these cytokines is currently performed using research assays and is not readily available as a clinically validated test.
Speaking at the British Science Festival in Swansea, report coauthor Dr Daisy Fancourt said evidence found as well as reductions in cortisol, singing also led to increases in the anti-inflammatory cytokines - IL17 and IL4.