interleukin-8

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interleukin-8

[‚in·tər¦lük·ən ′āt]
(immunology)
A group of peptides produced by a variety of cell types, which activate and recruit polymorphonuclear leukocytes in the inflammatory process, and are probably involved in initiation of labor and delivery in pregnant women. Abbreviated IL-8.
References in periodicals archive ?
Enhanced accumulation of neutrophils in the pocket epithelium and adjacent connective tissue of patients with chronic periodontitis and with generalized aggressive periodontitis (GAP)s was associated with the upregulation of IL8, intercellular adhesion molecule-1, IL-1b and TNF--a expression, which related to the severity and activity of generalized aggressive periodontitis.
The team discovered that whilst T cells in newborn babies are largely different to those in adults, it is not because they are immunosuppressed; rather, they manufacture a potent anti-bacterial molecule known as IL8 that has not previously been considered a major product of T cells, and that activates neutrophils to attack the body's foreign invaders.
3) Another study on the induced sputum of COPD patients suggests that elevated levels of IL6, IL8 and tumor necrosing factor alpha (TNFa) in such patients are correlated with pathogenesis and progression of COPD.
AP1 and NF-[kappa]B elicit the transcription of proinflammatory cytokines such as IL8, which stimulates the transmigration of neutrophils to the intestinal mucosa.
Vitiligo-inducing phenols activate the unfolded protein response in melanocytes resulting in upregulation of IL6 and IL8.
Esse biopolimero, apos ser desacetilado, tem a capacidade de ativar os macrofagos, que liberam IL6 e IL8 e outros fatores de crescimento, promovendo a cicatrizacao dos tecidos (UENO et al.
A hipotese proposta foi que em pacientes com DPOC a presenca da infeccao viral latente representava mais um estimulador da inflamacao, alem do tabagismo e das exacerbacoes infecciosas, levando a liberacao de maiores quantidades de mediadores inflamatorios, como o ICAM-1 e a IL8, e ampliando o processo inflamatorio ja instalado pelo tabagismo.
Also, other work has demonstrated the modulation of human intestinal epithelial cell IL8 secretion by human milk factors [12, 13].
The proinflammatory cytokine IL8 was assayed by ELISA (R&D-Systems).
Haelan 951 is a potent treatment for cancer that decreases pro-inflammatory cytokines including IL8 and promotes cell differentiation in five cancer cell lines in vitro, as shown in studies dating from 1990.