Our results suggest that IRAK1 has a crucial role in the development of drug resistance.
can block IRAK1 activity is highly likely to prevent tumour recurrence.
Our results demonstrated that the expression levels of TLR9, MYD88, IRAK1
, and NF-[kappa]B were not affected by different levels of HBV DNA, whereas TRAF6 was decreased in the patients with lower HBV DNA copy numbers.
Chandra Mohan, professor of internal medicine and senior author of the study, said that identifying IRAK1 as a disease gene may also have therapeutic implications.
Our work also shows that blocking IRAK1 action shuts down lupus in an animal model.
Pacritinib's potent inhibition of FLT3, c-fms, IRAK1 and c-kit, all critical targets in hematologic malignancies, highlights its potential therapeutic utility in other indications, such as AML, MDS, CMML and CLL.
Disruption in the c-fms and IRAK1 pathways have been indicated to be involved in acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), chronic myelomonocytic leukemia (CMML) and chronic lymphocytic leukemia (CLL).
The research team verified that an immune system enzyme called IRAK1
(Interleukin Receptor Associated Kinase-1) is highly over-expressed and hyper-activated in about 25 percent of MDS/AML cells.