idiotype

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idiotype

[′id·ē·ə‚tīp]
(immunology)
The unique amino acid sequence and corresponding three-dimensional structure of the variable region of an immunoglobulin molecule that determines its antigenic specificity.
References in periodicals archive ?
This test involves separation of EPO idiotypes by isoelectric focussing, immunoblotting, and detection of IgG labeled with streptiverdin-peroxidase.
While there have been numerous transgenic mice expressing human antibodies, this is the first genetic engineering project that resulted in an animal that makes antibodies with fully human idiotypes as well as wild type animals make their own antibodies.
Idiotypes can provoke anti-idiotypes, which in turn can provoke anti-idiotypes that attach to the initial provoker as well as to the anti-idiotype.