interleukin

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Related to Il-17: IL-2, IL-23

interleukin

a substance extracted from white blood cells that stimulates their activity against infection and may be used to combat some forms of cancer

interleukin

[‚in·tər′lü·kən]
(immunology)
Any of a class of proteins that are secreted mostly by macrophages and T lymphocytes and induce growth and differentiation of lymphocytes and hematopoietic stem cells.
References in periodicals archive ?
Recent studies show that IFN-beta downregulates expression of IL-17 in both humans and animals, (27,28) which may reveal a new mechanism of action of IFN-beta.
During RA priming, a broad range of cytokines were induced in Monocyte cells and it was found that IFN-[gamma] and IL-17 expressions were higher than that of IL-4 and IL-13.
Biz de calismamizda serum ve deri orneklerinde OPN, IFN-[gamma], TNF-[alpha], IL-12, IL-23, IL-17 duzeylerini degerlendirerek, psoriasis immunpatogenezinde OPN, Th1/Th17 yolaginin rolunun anlasilmasi, hastalik siddeti ile iliskisinin degerlendirilmesini ve tedaviye yonelik arastirmalar icin hedef molekullerin ortaya konulmasini amacladik.
Moreover, the release of IL-1[alpha], IL-6, MCP-1, TNF-[alpha], and KC were dependent on both ASC and caspase1 and partially dependent on Nlrp3; IL-17 was partially dependent on ASC and caspase1 but not on Nlrp3.
IL-17'nin osteoklastogenez ve kemik rezorpsiyonunu destekleyen enflamatuvar mediatorlerin salinimini tetikledigi (34) ve ayni zamanda IL-17 overekspresyonunun RANKL/OPG oraninda degisimlere yol acarak in vivo kemik erozyonunda etkili oldugu saptanmistir (44).
3] Nonstandard abbreviations: Th1, T helper 1 (cells); mAb, monoclonal antibody; apo B, apolipoprotein B; IL-17, interleukin-17.
IL-17 markedly up-regulates {beta}-defensin-2 expression in human airway epithelium via JAK and NF-{kappa}B signaling pathways.
Further, IL-1 alpha or IL-1 beta along with IL-23 can promote IL-17 secretion from memory T cells.
Several experimental and clinical evidences show that IL-17 family members are involved in specific inflammatory processes leading to the mobilization of granulocytes.