interleukin-6

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Related to Il-6: IL-1b, IL-8

interleukin-6

[‚in·tər¦lük·ən ′siks]
(immunology)
A cytokine derived from activated T lymphocytes that has many functions, including induction of B-cell growth; induction of B-cell differentiation and antibody production; induction of differentiation and proliferation of T cells; synergistic induction with IL-3 of hematopoietic cell growth; and induction of hepatocyte secretion of acute-phase inflammatory proteins. Abbreviated IL-6.
References in periodicals archive ?
The discovery of age-related increases in IL-6 isn't just about the effect of caregiving," comments epidemiologist Burton H.
This case study indicates that the onset of increasing IL-6 concentrations 3 h after catheter insertion most probably represents local production of IL-6 and not the circulating concentrations-which indicates that this sampling method may have limitations when time series of immune mediators (e.
The increased concentrations of IL-6 found when the third catheter was placed in a vein proximal to the previous site of insertion supports the contention that the high IL-6 values derive from local tissue production rather than from the catheter system itself.
The mRNA levels of pro-inflammatory cytokines TNF-[Alpha] and IL-6 in preparations from pooled pulmonary lymph nodes appeared to be lower in the feed-restricted group compared to the ad libitum group 7 days after HDM sensitization (Figure 7).
Although the mechanisms for this attenuation are unclear, reduced initial expression of the pro-inflammatory cytokines TNF-[Alpha] and IL-6 was associated with decreased allergic responses to HDM in feed-restricted animals.
Phase I/II clinical trials of IL-6 began in Europe and the United States in 1992 following regulatory approvals.
Evidence, produced in experimental models, indicates that IL-6 has a wide range of activities in the immune response.
Those individuals reporting pronounced stress in their lives produced the most mucus, displayed the largest surges in IL-6 production, and cited the most-severe symptoms of respiratory infection during the course of the study, the researchers say.
Because pathological levels of IL-1, IL-4, IL-6, IL-13 and VEGF seem to contribute to a variety of disease states, these Traps have the potential to be evaluated for use in a range of therapeutic indications.
Because pathological levels of IL-1, IL-4, IL-6 and IL-13 seem to contribute to a variety of disease states, these Cytokine Traps have the potential to be important therapeutic agents.