Imidazole

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Related to Imidazoles: clotrimazole, Triazoles

imidazole

[‚im·ə′da‚zōl]
(organic chemistry)
C3H4N2 One of a group of organic heterocyclic compounds containing a five-membered diunsaturated ring with two nonadjacent nitrogen atoms as part of the ring; the particular compound imidazole is a member of the group.

Imidazole

 

(glyoxaline, 1,3-diazole) a heterocyclic base. Colorless crystals; boiling point, 256°C. Imidazole is readily soluble i n water and alcohol and moderately soluble in ether. It is aromatic, that is, readily undergoes halogenation, nitration, and sulfonation. The hydrogen of the NH group can be replaced by alkyl by the action of, for example, dimethylsulfate. Imidazole is prepared by reacting glyoxalwith ammonia and formaldehyde. Its derivatives (histamin, histidine, carnosine, pilocarpine) are widely distributed in the animal and plant worlds and have important biological significance. [10–416-6 ]

References in periodicals archive ?
The results of the antimicrobial efficacy of the synthesized 2-substituted-4, 5-diphenyl imidazoles are expressed in Table 1.
The triazoles (ie, fiuconazole and itraconazole), licensed for general use in the 1990s, have the same mode of action as that of the imidazoles.
Also offers a wide range of imidazole accelerators, including 2-methylimida-zole, 2-ethyl-4-methylimidazole, and 2-phenylimidazole, as well as several developmental types.
The use of imidazole derivatives gives better results, but does not eliminate completely the previous objections [2].
In Switzerland, three triazoles (terconazole, itraconazole, fluconazole) and eight imidazoles (clotrimazole, miconazole, econazole, ketoconazole, tioconazole, isoconazole, oxiconazole, and fenticonazole) are in use (Documed AG 2002).
Imidazoles with long pot life, and high HDT, for potting, casting, and encapsulation.
The sensitive of mycelium, arthrospores and microconidia of Trichophyton mentagrophytes to imidazoles determined by in vitro tests.
Responses to imidazoles were unpredictable, and the patient with a brain abscess caused by A.
SAN DIEGO, March 26 /PRNewswire/ -- Ontogen Corporation, a drug discovery and development company, announced today that the United States (US) Patent and Trademark Office has issued a patent for the use of imidazoles as modulators that restore the sensitivity of multi-drug resistant cancer cells to chemotherapeutic agents.
Company also offers a wide range of imidazole accelerators, including 2-methylimidazole, 2-ethyl-4-methylimidazole, and 2-phenylimidazole, as well as several developmental imidazoles.
It is also known that imidazoles, such as clotrimazole, exhibit potent antiangiogenic effects.
Imidazole an alkaloid from plant secondary metabolites, is an important component of antifungal, anti protozoal, anti helminthic and anti cancer medications.