light chain

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light chain

[′līt ′chān]
(immunology)
The smaller of the two types of chains found in immunoglobulin molecules, molecular weight 23,500. Also known as B chain; L chain.
References in periodicals archive ?
Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): a consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis, Tours, France, 18-22 April 2004.
Increased concentrations of immunoglobulin light chains might be an indicator of B cell hyperactivity thereby reflecting disease activity better than other inflammation parameters when B cell involvement is suspected in the pathogenesis.
a high degree of specificity, so they recognize immunoglobulin light chains when they are free but not when they are bound to heavy chains in intact immunoglobulin molecules; and
Spectrum of glomerular and tubulointerstitial renal lesions associated with monotypical immunoglobulin light chain deposition.
Immunostains can be helpful in showing a histiocytic phenotype (ie, CD68 positive) as well as staining for immunoglobulin light chains.
Up to 80% of patients with LPL/WM will have monoclonal immunoglobulin light chains (Bence-Jones proteins) in the urine.
Immunofluorescence microscopy is usually helpful in delineating whether the amyloid is derived from the immunoglobulin light chains or heavy chains.
8) A significant minority of patients (15%-20%) (9,10) have light chain multiple myeloma, a form of the disease in which only immunoglobulin light chains are produced.
Highly sensitive, automated immunoassay for immunoglobulin light chains in serum and urine.
Commercial antibodies are raised against the constant regions of the respective immunoglobulin light chains.
Bence Jones proteins [monoclonal free immunoglobulin light chains (FLCs)] are important tumor markers for identifying and managing patients with monoclonal plasma cell diseases, particularly multiple myeloma.
Localization of a single binding site for immunoglobulin light chains on human Tamm-Horsfall glycoprotein.

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