proteasome

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proteasome

[′prōd·ē·ə‚sōm]
(biochemistry)
A large proteolytic particle found in the cytoplasm and nucleus of all eukaryotic cells that is the site for degradation of most intracellular proteins.
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References in periodicals archive ?
The combination of AbbVie's world-class expertise in immunology drug development with Principia's innovative approach to immunoproteasome inhibitors may offer patients a new class of therapies to treat serious and chronic conditions.
PSMB9 containing rs17587 at exon 4 encodes the immunoproteasome [sz]1 subunit possessing glutamyl peptide hydrolyzing activity in protein degradation and participates in the immune response to MHC Class I molecules.
MHCI presentation may be dependent upon the immunoproteasome in murine macrophages, but not routine dendritic cells.
As other clinical studies demonstrate interactions between PM exposure and allergic responses, further study of the immunoproteasome is indicated (Gilliland et al.
Some subjects discussed are molecular chaperones in normal and pathologic states, genetic polymorphism of immunoproteasome and its functional value, and genetic polymorphism of alpha-1-inhibitor of proteinases and its clinical value.
The immunoproteasome-specific antigen peptides are presented on the outer surface of the infected cell via immunoproteasome and MHC-1 processing allowing the T-cells to phagocyte the infected cells.
Thus, basic questions such as those related to possible consequences, for immune responses in infectious diseases and cancer, of age-related alterations of antigen processing and presenting, change with age of self-antigen repertoire, and the genetic basis of immunoproteasome activity and its change with age, remain largely unanswered.

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