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immunosuppression |
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immunosuppressionSuppression of immunity with drugs, usually to prevent rejection of an organ transplant. Its aim is to allow the recipient to accept the organ permanently with no unpleasant side effects. In some cases the dosage can be reduced or even stopped without causing rejection. Other uses are in the treatment of certain autoimmune diseases and for prevention of erythroblastosis fetalis. Its main drawback is the increased risk of infection for the duration of treatment and of lymphoma in the case of long-term immunosuppression. |
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The long-term use of immunosuppressants, danger of infection, high cost, scarcity of donors and unknown side effects, however, are problems that have yet to be solved, meaning that the quality of life (QOL) of patients is markedly reduced. The new Medicare drug coverage will rely on restrictive formularies as a cost-containment measure, although the federal government has promised substantial access to antidepressants, antipsychotics, anticonvulsants, HIV/AIDS drugs, cancer medications, and immunosuppressants (all of which could be subject to utilization controls, such as prior-authorization and step therapy mandates). Other recent research may lead to improved dosing for the immunosuppressants cyclosporine and tactolimus, which can cause kidney damage and failure. |
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Immunosuppressants
