immunotoxin

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immunotoxin

[‚im·yə·nō′täk·sən]
(immunology)
Conjugate of antibody and toxic protein such that the specificity of the antibody molecule is combined with the cytotoxic property of the toxin.
References in periodicals archive ?
Since immunotoxins function by directly killing the cells instead of inhibiting receptor-mediated signaling pathways, there can be less chance for tumor cells to upregulate rescue mutations or alternative signaling pathways to resist the immunotoxin therapy.
2000) Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity.
Administration of a CD25-directed immunotoxin, LMB-2, to patients with metastatic melanoma induces a selective partial reduction in regulatory T cells in vivo.
Moreover, lintuzumab conjugated with immunotoxin recombinant gelonin (HUM-195/rGEL) has been under investigation in patients with relapsed/refractory myeloid leukemias [108].
This makes it much easier for antibody-based drugs, known as immunotoxins, to attack the cancerous cells.
Polymorphisms of CD3e in cynomolgus and rhesus monkeys and their relevance to anti-CD3 antibodies and immunotoxins.
Immunotoxins made with the antibodies and antibody fragments of the invention have improved cytotoxicity to CD22-expressing cancer cells.
There are T-helper lymphocytes that are involved with delayed allergy reactions to haptenic immunotoxins such as toxic minerals.
Triphenyltin pesticides in sea water as immunotoxins for tunicates.
Immunotoxins are drugs created by linking an antibody to a portion of bacterial or plant toxin to destroy cells expressing the molecule to which the antibody binds.