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in situ hybridization |
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in situ hybridization [‚in ‚si·chü ‚hī·brəd·ə·zā·shən] (cell and molecular biology) A technique permitting identification of particular deoxyribonucleic acid or ribonucleic acid sequences while these sequences remain in their original location in the cell. A cell or tissue is treated with a fixative and then exposed to a labeled (by radioactivity or fluorescence) single-stranded nucleic acid probe that hybridizes with the targeted nucleic acid sequence, revealing its location on a chromosome band when the hybridized sequence is analyzed microscopically. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Use of fluorescence in situ hybridisation (FISH) to assess effects of smoking, caffeine, and alcohol on aneuploidy load in sperm of healthy men. |
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