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in situ hybridization |
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in situ hybridization [‚in ‚si·chü ‚hī·brəd·ə·zā·shən] (cell and molecular biology) A technique permitting identification of particular deoxyribonucleic acid or ribonucleic acid sequences while these sequences remain in their original location in the cell. A cell or tissue is treated with a fixative and then exposed to a labeled (by radioactivity or fluorescence) single-stranded nucleic acid probe that hybridizes with the targeted nucleic acid sequence, revealing its location on a chromosome band when the hybridized sequence is analyzed microscopically. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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New models include chemically resistant ceramic top stirrer hotplates, which are available in two large sizes, and sophisticated metal top digital models with excellent temperature control for applications such as in-situ hybridisation, microarraying, and the fixing of microscope slides. Donor age and the frequency of disomy for chromosomes 1,13,21 and structural abnormalities in human spermatozoa using multicolour fluorescence in-situ hybridisation. With regard to technology, hybridisation techniques tend to be the major technologies utilised in the field of pharmacogenomics, and fluorescence in-situ hybridisation (FISH) continues to be widely used due to its ability to detect a variety of chromosomal and genetic aberrations such as molecular translocation deletions specific to each entity of haematological malignancies in a single non-dividing interphase cell. |
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