Indole

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indole

[′in‚dōl]
Also known as 2,3-benzopyrrole.
(biochemistry)
C6H4-(CHNH)CH A decomposition product of tryptophan formed in the intestine during putrefaction and by certain cultures of bacteria.
(organic chemistry)
Carcinogenic, white to yellowish scales with unpleasant aroma; soluble in alcohol, ether, hot water, and fixed oils; melt at 52°C; used as a chemical reagent and in perfumery and medicine.

Indole

 

(2, 3-benzopyrrole), colorless crystals with an unpleasant odor. Melting point, 52°C; boiling point, 254°C. It is soluble in hot water and organic solvents. Indole is present in coal tar, from which it is extracted as salts of alkali metals, as well as in certain essential oils (for example, oil of jasmine). Along with skatole (3-methyl-indole), it is found in the intestines of human beings and mammals.

Many indole derivatives, for example, 3-indoleacetic acid (heteroauxin A, a growth substance), serotonin, and reserpine, are biologically active. Indole is a raw material for synthesizing heteroauxin and tryptophane, and is used in the perfumery industry to improve and strengthen the scents of flower essences.

References in periodicals archive ?
Antileishmanial activity of indole alkaloids from Aspidosperma ramifIorum.
Chemistry and pharmacology of analgesic indole alkaloids from the rubeaceous plant, Microgyria speciosa.
Monoterpene indole alkaloids consist in a terpenoid component derived from the iridoid glucoside secologanin and an indole moiety provided by triptamine (Facchini 2001).
Chemical analysis of AE identified 10-methoxygeis-soschizol, ramiflorine A and ramiflorine B, corynanthe monoterpernoid indole alkaloids, as its major constituents (Ferreira et al.
Treatment with the indole alkaloid physostigmine [1], an AChE inhibitor isolated from P.
The most pharmacologically active indole alkaloids are ajmaline, deserpidine, rescinnamine, reserpine, serpentine, and yohimbine.
Indole alkaloids and coumarins from the root bark of Murraya paniculata var.
Chemical studies on the analgesic indole alkaloids from the traditional medicine (Miragyna speciosa) used for opium substitute.
It has also been suggested that these five enzymes relate to the biosynthesis of terpenoid indole alkaloids of T.
Indole alkaloids often present, iridoid glycosides and cardenolides less frequently.
Nauclea species have been reported to produce interesting bioactive phytochemicals, in particular monoterpenoid indole alkaloids such as 10-(anti-proliferative) (Erdelmeier et al.