Indole

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Related to Indole ring: tryptophan, pyrrole ring

indole

[′in‚dōl]
Also known as 2,3-benzopyrrole.
(biochemistry)
C6H4-(CHNH)CH A decomposition product of tryptophan formed in the intestine during putrefaction and by certain cultures of bacteria.
(organic chemistry)
Carcinogenic, white to yellowish scales with unpleasant aroma; soluble in alcohol, ether, hot water, and fixed oils; melt at 52°C; used as a chemical reagent and in perfumery and medicine.

Indole

 

(2, 3-benzopyrrole), colorless crystals with an unpleasant odor. Melting point, 52°C; boiling point, 254°C. It is soluble in hot water and organic solvents. Indole is present in coal tar, from which it is extracted as salts of alkali metals, as well as in certain essential oils (for example, oil of jasmine). Along with skatole (3-methyl-indole), it is found in the intestines of human beings and mammals.

Many indole derivatives, for example, 3-indoleacetic acid (heteroauxin A, a growth substance), serotonin, and reserpine, are biologically active. Indole is a raw material for synthesizing heteroauxin and tryptophane, and is used in the perfumery industry to improve and strengthen the scents of flower essences.

References in periodicals archive ?
Indeed, their studies showed, chemicals that posses a structure known as an indole ring -- including the essential amino acids L-tryptophan and L-proline -- provide "a more specific means of lowering the formation of mutagens" than had the antioxidants.
In contrast, uremic toxins that contain an indole ring and HA were primarily bound to site II, another major drug-binding area, which is located in subdomain IIIA of the HSA structure [17].
The indole ring attacks on the carbonyl carbon to form a tetrahedron intermediate (a) and eliminates HOI to form intermediate (b).