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initiation codon

   Also found in: Dictionary/thesaurus, Medical, Legal, Wikipedia 0.01 sec.
initiation codon [i‚nish·ē′ā·shən ′kō‚dän]
(genetics)
A codon that signals the first amino acid in a protein sequence; usuallyAUG, but sometimesGUG. Also known as start codon.


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This occurs because of a complementarity between a sequence at the 3' end of 16S rRNA and the Shine-Dalgarno (SD) sequence just 5' to the initiation codon (Shine and Dalgarno, 1974; Gualerzi and Pon, 1990).
A second in-frame initiation codon is at nucleotide position 93-95, in the same position as the start codon of the 10,200 strain.
Even in the absence of a Shine-Dalgamo homology, for example, translational repression of the aph coding region of a mutant mRNA expressed in Streptomyces lividans is relieved when a short leader is adde d upstream of an extra 5'-terminal initiation codon [10].
 
 
 
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