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integrase

   Also found in: Medical, Wikipedia 0.01 sec.
integrase [′int·ə‚grās]
(biochemistry)
An enzyme that facilitates prophage integration into or excision from a bacterial chromosome.


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describe the recent developments in targeting viral integrase.
Both Monogram's Integrase phenotype and genotype assays were used in Elvitegravir preclinical and Phase II studies, and will be used to evaluate Phase III patient outcomes.
The papers focus on a range of chromosomal mutagenesis techniques for both prokaryotic and eukaryotic organisms, and present a variety of state-of-the-art methods in step-by-step laboratory format, including insertional gene disruptions, gene knockouts, stimulated homologous recombination techniques and novel tools based on integrases, eukaryotic transposons, triplex forming oligonucleotides, group II introns, and engineered site-directed nucleases.
 
 
 
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