integrase

(redirected from Integrases)
Also found in: Medical.

integrase

[′int·ə‚grās]
(biochemistry)
An enzyme that facilitates prophage integration into or excision from a bacterial chromosome.
References in periodicals archive ?
The book's first 12 chapters deal with the basic biology and structural understanding of HIV-1 integrase, with descriptions of the HIV life cycle, targets for anti-HIV agents, and integrase mechanisms and functions, along with a review of structural studies of retroviral integrases.
The papers focus on a range of chromosomal mutagenesis techniques for both prokaryotic and eukaryotic organisms, and present a variety of state-of-the-art methods in step-by-step laboratory format, including insertional gene disruptions, gene knockouts, stimulated homologous recombination techniques and novel tools based on integrases, eukaryotic transposons, triplex forming oligonucleotides, group II introns, and engineered site-directed nucleases.
HIV-1 integrase inhibitor design: Overview and historical perspectives (Nouri Neamati (USC))
HIV integrase inhibitors: from diketoacids to heterocyclic templates: A history of HIV integrase medicinal chemistry at Merck West Point and Merck Rome (IRBM) leading to the discovery of raltegravir
Discovery and development of natural product inhibitors of HIV-1 integrase
Azaindole hydroxamic acids are hiv-1 integrase inhibitors
A simple and accurate in vitro method for predicting serum protein binding of hiv integrase strand transfer inhibitors
Elvitegravir, a novel quinolone HIV-1 integrase strand transfer inhibitor
Conformationally constrained tricyclic HIV integrase inhibitors
Slow onset kinetics of HIV integrase inhibitors and proposed molecular model