integrin

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integrin

[in′teg·rən]
(cell molecular)
A heterodimeric transmembrane receptor protein of animal cells that binds to components of the extracellular matrix on the outside of a cell and to the cytoskeleton on the inside of the cell, functionally connecting the cell interior to its exterior; in blood cells, integrins are also involved in cell-cell adhesion.
References in periodicals archive ?
United States patent number 5,510,332 is entitled "A PROCESS TO INHIBIT BINDING OF THE INTEGRIN ALPHA4 BETA1 [VLA-4] TO VCAM-1 OR FIBRONECTIN AND LINEAR PEPTIDES THEREFORE" and was issued April 23, 1996.
These are the Anti-Insulin-like Growth Factor-1 (Anti-IGF-I) receptor monoclonal antibody and replication competent oncolytic virus, whose mechanism of action works by binding to Integrin Alpha4 (ITGA4) expressing CHOK1 and H446.